Leptospirosis is an invasive infectious and systemic inflammatory disease
| Autor: | Jie Yan, Xiao-Xiang Liu, Ai-Hua Sun |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Virulence Endocytic recycling Review Article Pathogenesis Communicable Diseases Microbiology 03 medical and health sciences 0302 clinical medicine Pathogenic mechanism Bacterial Proteins Leptospira Medicine Animals Humans Leptospirosis Letter to the Editor lcsh:QH301-705.5 Inflammation lcsh:R5-920 biology business.industry Hemolysin General Medicine biology.organism_classification medicine.disease Extracellular Matrix 030104 developmental biology lcsh:Biology (General) Infectious disease (medical specialty) 030220 oncology & carcinogenesis Leptospira interrogans business lcsh:Medicine (General) |
| Zdroj: | Biomedical Journal, Vol 43, Iss 1, Pp 24-31 (2020) Biomedical Journal |
| ISSN: | 2319-4170 |
| Popis: | Pathogenic Leptospira species are the causative agents of leptospirosis, a world-spreading zoonotic infectious disease. The pathogens possess a powerful invasiveness by invading human body through mucosal/skin barriers, rapid entry into bloodstream to cause septicemia, diffusion from bloodstream into internal organs and tissues to cause aggravation of disease, and discharge from urine through renal tubules to form natural infectious sources. Leptospirosis patients present severe inflammatory symptoms such as high fever, myalgia and lymphadenectasis. Hemorrhage and jaundice are the pathological features of this disease. Previous studies revealed that some outer membrane proteins of Leptospira interrogans, the most important pathogenic Leptospira species, acted as adherence factors to binding to receptor molecules (fibronectin, laminin and collagens) in extracellular matrix of host cells. Collagenase, metallopeptidases and endoflagellum contributed to the invasiveness of L. interrogans. Except for lipopolysaccharide, multiple hemolysins of L. interrogans displayed a powerful ability to induce pro-inflammatory cytokines and hepatocyte apoptosis. vWA and platelet activating factor acetylhydrolase-like proteins from L. interrogans could induce severe pulmonary hemorrhage in mice. L. interrogans utilized cellular endocytic recycling and vesicular transport systems for intracellular migration and transcellular transport. All the research achievements are helpful for further understanding the virulence of pathogenic Leptospira species and pathogenesis of leptospirosis. Keywords: Leptospira, Virulence, Pathogenic mechanism, Leptospirosis, Pathogenesis |
| Databáze: | OpenAIRE |
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