Effects of Lactobacillus plantarum CJLP55 on Clinical Improvement, Skin Condition and Urine Bacterial Extracellular Vesicles in Patients with Acne Vulgaris: A Randomized, Double-Blind, Placebo-Controlled Study
| Autor: | Hee-Yoon Ahn, Yunhi Cho, Mi-Ju Kim, June-Hyuck Yim, Chunpil Choi, Kun-Pyo Kim, Hyun-Sun Yun, Eunhye Choi, Ji-Young Oh |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Male
0301 basic medicine Firmicutes Lactobacillus plantarum CJLP55 Placebo-controlled study Urine Pharmacology Placebo sebum Article Extracellular Vesicles Young Adult 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine Double-Blind Method medicine Humans acne vulgaris TX341-641 Triglycerides Acne Skin Nutrition and Dietetics biology integumentary system business.industry Nutrition. Foods and food supply Bacteroidetes Hydrogen-Ion Concentration biology.organism_classification medicine.disease Treatment Outcome 030104 developmental biology Dietary Supplements Dysbiosis Female urine bacterial extracellular vesicles business Lactobacillus plantarum hydration Food Science |
| Zdroj: | Nutrients, Vol 13, Iss 1368, p 1368 (2021) Nutrients Volume 13 Issue 4 |
| ISSN: | 2072-6643 |
| Popis: | Lactobacillus plantarum CJLP55 has anti-pathogenic bacterial and anti-inflammatory activities in vitro. We investigated the dietary effect of CJLP55 supplement in patients with acne vulgaris, a prevalent inflammatory skin condition. Subjects ingested CJLP55 or placebo (n = 14 per group) supplements for 12 weeks in this double-blind, placebo-controlled randomized study. Acne lesion count and grade, skin sebum, hydration, pH and surface lipids were assessed. Metagenomic DNA analysis was performed on urine extracellular vesicles (EV), which indirectly reflect systemic bacterial flora. Compared to the placebo supplement, CJLP55 supplement improved acne lesion count and grade, decreased sebum triglycerides (TG), and increased hydration and ceramide 2, the major ceramide species that maintains the epidermal lipid barrier for hydration. In addition, CJLP55 supplement decreased the prevalence of Proteobacteria and increased Firmicutes, which were correlated with decreased TG, the major skin surface lipid of sebum origin. CJLP55 supplement further decreased the Bacteroidetes:Firmicutes ratio, a relevant marker of bacterial dysbiosis. No differences in skin pH, other skin surface lipids or urine bacterial EV phylum were noted between CJLP55 and placebo supplements. Dietary Lactobacillus plantarum CJLP55 was beneficial to clinical state, skin sebum, and hydration and urine bacterial EV phylum flora in patients with acne vulgaris. |
| Databáze: | OpenAIRE |
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