A nerve growth factor peptide retards seizure development and inhibits neuronal sprouting in a rat model of epilepsy
| Autor: | R. J. Riopelle, Ronald J. Racine, Gregory M. Ross, J. Stanisz, C A Chapman, Margaret Fahnestock, Kashif Rashid, C. E. E. M. Van Der Zee |
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| Rok vydání: | 1995 |
| Předmět: |
Mossy fiber (hippocampus)
Male Hippocampus Nerve Tissue Proteins Neurotrophin-3 Receptors Nerve Growth Factor Superior Cervical Ganglion Epilepsy Nerve Fibers Neurotrophin 3 Seizures Ganglia Spinal medicine Kindling Neurologic Animals Nerve Growth Factors Brain-derived neurotrophic factor Multidisciplinary biology Chemistry Kindling Histocytochemistry Brain-Derived Neurotrophic Factor Anatomy medicine.disease Electric Stimulation Peptide Fragments Rats Nerve growth factor nervous system biology.protein Biological Assay Ganglia Neuroscience Neurotrophin Research Article |
| Zdroj: | Proceedings of the National Academy of Sciences of the United States of America. 92(21) |
| ISSN: | 0027-8424 |
| Popis: | Kindling, an animal model of epilepsy wherein seizures are induced by subcortical electrical stimulation, results in the upregulation of neurotrophin mRNA and protein in the adult rat forebrain and causes mossy fiber sprouting in the hippocampus. Intraventricular infusion of a synthetic peptide mimic of a nerve growth factor domain that interferes with the binding of neurotrophins to their receptors resulted in significant retardation of kindling and inhibition of mossy fiber sprouting. These findings suggest a critical role for neurotrophins in both kindling and kindling-induced synaptic reorganization. |
| Databáze: | OpenAIRE |
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