Unresectable Squamous Cell Carcinoma of Donor Origin Treated With Immunosuppression Withdrawal and Liver Retransplantation
| Autor: | Wilbur B. Bowne, Charles M. Miller, Leona Kim-Schluger, Ruoqing Huang, Sander Florman, M. Fotino, Myron Schwartz, Swan N. Thung, Max Sung |
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| Rok vydání: | 2004 |
| Předmět: |
Adult
Reoperation Pathology medicine.medical_specialty medicine.medical_treatment Human leukocyte antigen Histocompatibility Testing Liver transplantation Malignancy Liver disease Humans Immunology and Allergy Medicine Pharmacology (medical) Pathological Transplantation business.industry Liver Neoplasms Immunosuppression Middle Aged medicine.disease Tissue Donors Liver Transplantation Carcinoma Squamous Cell Female business Complication |
| Zdroj: | American Journal of Transplantation. 4:278-282 |
| ISSN: | 1600-6135 |
| DOI: | 10.1046/j.1600-6143.2003.00322.x |
| Popis: | Posttransplantation allograft malignancy of donor origin is a rare complication after liver transplantation. In the case described, subjective fevers and nonspecific abdominal complaints nearly 6 months following cadaveric liver transplantation in a young woman prompted an evaluation which was remarkable for a large central liver mass. A poorly differentiated squamous cell carcinoma was diagnosed, but was unresectable at exploration. The tumor was confined to the liver. Histocompatibility testing using polymerase chain reaction (PCR) amplification techniques identified both donor and recipient HLA alleles. The patient was treated with chemoembolization, systemic chemotherapy and cessation of immunosuppression. Repeat biopsy 2 months later showed the tumor to be completely necrotic. With decompensated liver disease, she was relisted and retransplanted. More than 2 years later she remains disease-free with complete pathological remission. This is the only reported case of squamous cell carcinoma of donor origin arising in a transplanted liver. |
| Databáze: | OpenAIRE |
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