Development of 5, 3 -Hydroxysteroid and Glucose-6-Phosphate Dehydrogenase in the Testes, Adrenals and Ovaries of the Rabbit Fetus
| Autor: | Allen S. Goldman, Albert E. Stanek, Mary K. Baker |
|---|---|
| Rok vydání: | 1972 |
| Předmět: |
Male
medicine.medical_specialty Chromatography Gas Hypophysectomy medicine.medical_treatment Gestational Age Ovary Glucosephosphate Dehydrogenase Biology Tritium General Biochemistry Genetics and Molecular Biology chemistry.chemical_compound Fetus Pregnancy Internal medicine Adrenal Glands Testis Methods medicine Animals Orchiectomy Sexual differentiation Glycogen Histocytochemistry Hydroxysteroid Dehydrogenases Endocrinology medicine.anatomical_structure chemistry embryonic structures Gestation Female Chromatography Thin Layer Rabbits Cortisone medicine.drug |
| Zdroj: | Experimental Biology and Medicine. 140:1486-1492 |
| ISSN: | 1535-3699 1535-3702 |
| Popis: | The classical work of Jost demonstrating the fetal testicular control of masculine differentiation was performed in the rabbit (1). Orchiectomy produced testosterone-reversible blockade of androgen-dependent masculine development between days 19 and 22 of gestation but had no effect after day 22. Decapitation, performed on male fetuses before day 22, resulted in a gonadotropin-reversible partial block in masculine differentiation manifested by hypospadias, suggesting that hypophysectomy induced deficient testicular function. The fetal ovary did not play a role in sexual differentiation of the rabbit fetus. Jost has also shown that there is a pituitary-dependent early period of growth of the rabbit fetal adrenal cortex between days 20 and 25 (2). From day 25 to day 28 he has demonstrated a cortisone- and ACTH-dependent increase in fetal liver glycogen, which does not occur in adrenalectomized or decapitated fetuses in pregnant rats whose corticosteroid production is eliminated by adrenalectomy.Conversion o... |
| Databáze: | OpenAIRE |
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