Microthymoma
| Autor: | Wah Cheuk, John K. Chan, William Y.W. Tsang |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Thymoma CD3 Complex T-Lymphocytes medicine.medical_treatment Pure red cell aplasia Thymus Gland Biology Pathology and Forensic Medicine Gross examination DNA Nucleotidylexotransferase hemic and lymphatic diseases Biomarkers Tumor medicine Humans Microscopic Thymoma Hyperplasia Focal nodular hyperplasia Thymus Neoplasms Anatomy Middle Aged medicine.disease Immunohistochemistry Myasthenia gravis Thymectomy Treatment Outcome Surgery |
| Zdroj: | The American Journal of Surgical Pathology. 29:415-419 |
| ISSN: | 0147-5185 |
| DOI: | 10.1097/01.pas.0000152130.58492.de |
| Popis: | We report 2 cases of microscopic-sized thymoma, which probably represents the earliest phase of thymoma development. The 2 patients presented with pure red cell aplasia and myasthenia gravis, respectively. The thymectomy specimens did not reveal tumor on gross examination, but histologically each contained small thymomas measuring 5 mm and 7 mm in largest dimension, respectively. One of the tumors was unencapsulated and involved a single lobule only, and the other was encapsulated and comprised two lobules. The tumors consisted of ovoid epithelial cells with pale nuclei and distinct nucleoli, scattered in a background of small lymphocytes. Foci of medullary differentiation and perivascular space were identified in the 2 cases, respectively. The lymphocytes were confirmed to be immature T cells on immunohistochemical studies (CD3+, TdT+). Except for the microscopic size, the morphology of the two tumors conforms to conventional type B1/B2 and type B2 thymoma, respectively. We propose calling such incidental small tumor "microthymoma" to distinguish it from the so-called microscopic thymoma, which is composed of small thymic epithelial nests and probably more appropriately termed "nodular hyperplasia" of the thymic epithelium. |
| Databáze: | OpenAIRE |
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