Attenuation of cognitive impairment by the nonbacteriolytic antibiotic daptomycin in Wistar rats submitted to pneumococcal meningitis
| Autor: | João Quevedo, Tatiana Barichello, Cintia Silvestre, Caroline S. Costa, Graziele L. Milioli, Jaqueline da Rosa Coelho, Clarissa M. Comim, Joao Carlos Nepomuceno Goncalves, Jaqueline S. Generoso |
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| Rok vydání: | 2013 |
| Předmět: |
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Hearing loss medicine.drug_class Antibiotics medicine.disease_cause Cellular and Molecular Neuroscience Daptomycin Memory Streptococcus pneumoniae Avoidance Learning Reaction Time medicine Animals Memory impairment Meningitis Rats Wistar Habituation Analysis of Variance Behavior Meningitis Pneumococcal business.industry General Neuroscience Recognition Psychology medicine.disease Anti-Bacterial Agents Rats Disease Models Animal Inhibition Psychological Anesthesia Immunology Exploratory Behavior Ceftriaxone medicine.symptom Cognition Disorders business Research Article medicine.drug |
| Zdroj: | BMC Neuroscience |
| ISSN: | 1471-2202 |
| DOI: | 10.1186/1471-2202-14-42 |
| Popis: | Background: Streptococcus pneumoniae is associated with neurologic sequels, such as, seizures, sensory-motor deficits, hearing loss, learning and memory impairment, which can occur in approximately 30 to 52% of surviving patients. Neuronal damage can be caused by intense inflammatory reaction and direct effects of the bacteria virulence factors. The aim of the present study was to evaluate the effects of the nonbacteriolytic antibiotic daptomycin versus ceftriaxone on behavioral parameters in adult Wistar rats submitted to pneumococcal meningitis. Results: Ten days after induction we verified that the meningitis group with daptomycin treatment showed retention of aversive memory; it presented memory of the object recognition at short term and long term. In continuous multiple-trials step-down inhibitory avoidance task the meningitis group with ceftriaxone treatment required approximately two times more stimulus to reach the acquisition criterion when compared with meningitis group with daptomycin treatment. However, in the habituation memory test there were no differences in the number of crossings and rearings in training and task sessions demonstrating habituation impairment to the environment task in both meningitis groups. Conclusions: The evidence of the present study shows the potential alternative of the treatment with daptomycin in preventing learning and memory impairments caused by pneumococcal meningitis. Further investigations are necessary to provide support for evaluation of daptomycin as an alternative treatment of bacterial meningitis. |
| Databáze: | OpenAIRE |
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