In Vivo Gastroprotective and Antidepressant Effects of Iridoids, Verbascoside and Tenuifloroside from Castilleja tenuiflora Benth
| Autor: | Gabriela Trejo-Tapia, Alejandro Zamilpa, Manasés González-Cortazar, Blanca Eda Domínguez-Mendoza, Ricardo López-Rodríguez, Maribel Herrera-Ruiz |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
cold-restraint stress
Pharmaceutical Science verbascoside 01 natural sciences NERVOUS DISORDERS Analytical Chemistry lcsh:QD241-441 chemistry.chemical_compound Verbascoside Castilleja tenuiflora benth lcsh:Organic chemistry In vivo Drug Discovery Physical and Theoretical Chemistry tenuifloroside antidepressant Traditional medicine 010405 organic chemistry Chemistry Organic Chemistry gastroprotective Tail suspension test 0104 chemical sciences 010404 medicinal & biomolecular chemistry Castilleja tenuiflora Chemistry (miscellaneous) Polyphenol Molecular Medicine Antidepressant Behavioural despair test |
| Zdroj: | Molecules, Vol 24, Iss 7, p 1292 (2019) Molecules Volume 24 Issue 7 |
| ISSN: | 1420-3049 |
| Popis: | Stress is an important factor in the etiology of some illnesses such as gastric ulcers and depression. Castilleja tenuiflora Benth. (Orobanchaceae) is used in Mexican traditional medicine for the treatment of gastrointestinal diseases and nervous disorders. Previous studies indicated that organic extracts from C. tenuiflora had gastroprotective effects and antidepressant activity. In this study, we aimed to evaluate the gastroprotective and antidepressant activity of fractions and isolated compounds from the methanolic extract (MECt) of C. tenuiflora in stressed mice. Chromatographic fractionation of MECt produced four fractions (FCt-1, FCt-2, CFt-3, and FCt-4) as well as four bioactive compounds which were identified using TLC, HPLC and NMR analyses. The cold restraint stress (CRS)-induced gastric ulcer model followed by the tail suspension test and the forced swim test were used to evaluate the gastroprotective effect and antidepressant activity of the extract fractions. FCt-2 and FCt-3 at 100 mg/kg had significant gastroprotective and antidepressant effects. All isolated compounds (verbascoside, teniufloroside and mixture geniposide/ musseanoside) displayed gastroprotective effects and antidepressant activity at 1 or 2 mg/kg. The above results allow us to conclude that these polyphenols and iridoids from C. tenuiflora are responsible for the gastroprotective and antidepressant effects. |
| Databáze: | OpenAIRE |
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