Healthy ageing of cloned sheep
| Autor: | Inchul Choi, Alexandra J. Rathbone, Sandra A. Corr, Kevin D. Sinclair, Keith H.S. Campbell, Ju-Haeng Lee, David S. Gardner, Patricia A. Fisher, Carlos G. Gutiérrez |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Aging Systole Cloning Organism Science General Physics and Astronomy Physiology Blood Pressure Osteoarthritis Biology General Biochemistry Genetics and Molecular Biology Article 03 medical and health sciences Insulin resistance Animal science Heart Rate medicine Animals Adiposity Cloning Glucose tolerance test Multidisciplinary Sheep medicine.diagnostic_test Angiotensin II General Chemistry Glucose Tolerance Test medicine.disease Embryo Transfer Magnetic Resonance Imaging 030104 developmental biology Blood pressure Cohort Body Composition Somatic cell nuclear transfer Joints Insulin Resistance |
| Zdroj: | Nature Communications Nature Communications, Vol 7, Iss 1, Pp 1-10 (2016) |
| ISSN: | 2041-1723 |
| Popis: | The health of cloned animals generated by somatic-cell nuclear transfer (SCNT) has been of concern since its inception; however, there are no detailed assessments of late-onset, non-communicable diseases. Here we report that SCNT has no obvious detrimental long-term health effects in a cohort of 13 cloned sheep. We perform musculoskeletal assessments, metabolic tests and blood pressure measurements in 13 aged (7–9 years old) cloned sheep, including four derived from the cell line that gave rise to Dolly. We also perform radiological examinations of all main joints, including the knees, the joint most affected by osteoarthritis in Dolly, and compare all health parameters to groups of 5-and 6-year-old sheep, and published reference ranges. Despite their advanced age, these clones are euglycaemic, insulin sensitive and normotensive. Importantly, we observe no clinical signs of degenerative joint disease apart from mild, or in one case moderate, osteoarthritis in some animals. Our study is the first to assess the long-term health outcomes of SCNT in large animals. Since the birth of the first cloned animal, Dolly the sheep, concerns have been raised about potential long-term health consequences of cloning. Here the authors report on a cohort of 13 aged cloned sheep, including four created from the same cells as Dolly, and find they are healthy and seem to age normally. |
| Databáze: | OpenAIRE |
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