Expression profile of components of the β-catenin destruction complex in oral dysplasia and oral cancer
| Autor: | Montserrat Reyes, Goñi Fj, Torres Va, Peña-Oyarzún D |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Mild Dysplasia
Adenomatous polyposis coli Malignant transformation malignant Oral Cancer and Potentially malignant disorders Humans Medicine Wnt Signaling Pathway General Dentistry GSK3B beta Catenin UNESCO:CIENCIAS MÉDICAS Oral Dysplasia Axin Signaling Complex Glycogen Synthase Kinase 3 beta biology Squamous Cell Carcinoma of Head and Neck business.industry Research Wnt signaling pathway Cancer floor of the mouth medicine.disease stomatognathic diseases Otorhinolaryngology Catenin Carcinoma Squamous Cell biology.protein Cancer research Mouth Neoplasms epidemiology Surgery benign business |
| Zdroj: | Goñi, FJ., Peña‑Oyarzún, D., Torres, VA., & Reyes, M. (2021). Expression profile of components of the β-catenin destruction complex in oral dysplasia and oral cancer. En Medicina Oral Patología Oral y Cirugia Bucal (pp. e729-e737). Medicina Oral, S.L. https://doi.org/10.4317/medoral.24528 Medicina Oral, Patología Oral y Cirugía Bucal |
| ISSN: | 1698-6946 |
| DOI: | 10.4317/medoral.24528 |
| Popis: | Background Oral cancer represents the sixth most common cancer in the world and is associated with 40-50% survival at 5 years. Within oral malignancies, oral squamous cell carcinoma (OSCC) is commonly preceded by potentially malignant lesions, which, according to histopathological criteria, are referred to as oral dysplasia and their diagnosis are associated with higher rates of malignant transformation towards cancer. We recently reported that aberrant activation of the Wnt/β‑catenin pathway is due to overexpression of Wnt ligands in oral dysplasia. However, the expression of other regulators of this pathway, namely components of the β-catenin destruction complex has not been explored in oral dysplasia. Material and Methods Using immunohistochemical analyses, we evaluated nuclear expression of β‑catenin and its association with Wnt3a and Wnt5a. Likewise, components of the β-catenin destruction complex, including Adenomatous Polyposis Coli (APC), Axin and Glycogen Synthase Kinase 3 beta (GSK-3β) were also evaluated in oral dysplasia and OSCC biopsies. Results We found that moderate and severe dysplasia samples, which harbored increased expression of nuclear β‑catenin, depicted augmented cytoplasmic expression of GSK‑3β, Axin and APC, in comparison with OSCC samples. Also, GSK-3β was found nuclear in mild dysplasia and OSCC samples, when compared with other study samples. Conclusions Cytoplasmic levels of components of the β-catenin destruction complex are increased in oral dysplasia and might be responsible of augmented nuclear β‑catenin. Key words:Oral cancer, oral dysplasia, β-Catenin, Wnt ligands, destruction complex. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|