Analysis of Progression Time in Pancreatic Cancer including Carcinoma In Situ Based on Magnetic Resonance Cholangiopancreatography Findings
| Autor: | Masatoshi Kudo, Akihiro Yoshida, Ken Kamata, Mamoru Takenaka, Masakatsu Tsurusaki, Takaaki Chikugo, Ayana Okamoto, Kosuke Minaga, Tomohiro Yamazaki, Hidekazu Tanaka, Kota Takashima, Shunsuke Omoto, Yasutaka Chiba, Tomohiro Watanabe, Kentaro Yamao |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Medicine (General)
medicine.medical_specialty Clinical Biochemistry Article Lesion R5-920 Pancreatic cancer medicine Growth speed Pancreatic duct Magnetic resonance cholangiopancreatography Tumor size medicine.diagnostic_test pancreatic carcinoma business.industry Carcinoma in situ carcinoma in situ computed tomography medicine.disease Stenosis medicine.anatomical_structure magnetic resonance cholangiopancreatography natural history Radiology medicine.symptom business early diagnosis |
| Zdroj: | Diagnostics Diagnostics, Vol 11, Iss 1858, p 1858 (2021) Volume 11 Issue 10 |
| ISSN: | 2075-4418 |
| Popis: | Background: Pancreatic cancer (PC) exhibits extremely rapid growth however, it remains largely unknown whether the early stages of PC also exhibit rapid growth speed equivalent to advanced PC. This study aimed to investigate the natural history of early PCs through retrospectively assessing pre-diagnostic images. Methods: We examined the data of nine patients, including three patients with carcinoma in situ (CIS), who had undergone magnetic resonance cholangiopancreatography (MRCP) to detect solitary main pancreatic duct (MPD) stenosis > 1 year before definitive PC diagnosis. We retrospectively analyzed the time to diagnosis and first-time tumor detection from the estimated time point of first-time MPD stenosis detection without tumor lesion. Results: The median tumor size at diagnosis and the first-time tumor detection size were 14 and 7.5 mm, respectively. The median time to diagnosis and first-time tumor detection were 26 and 49 months, respectively. Conclusions: No studies have investigated the PC history, especially that of early PCs, including CIS, based on the initial detection of MPD stenosis using MRCP. Assessment of a small number of patients showed that the time to progression can take several years in the early PC stages. Understanding this natural history is very important in the clinical setting. |
| Databáze: | OpenAIRE |
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