Evaluation of the influence of age on pulmonary arterial pressure by use of right ventricular catheterization, pulsed-wave Doppler echocardiography, and pulsed-wave tissue Doppler imaging in healthy Beagles
| Autor: | Cécile Clercx, Charlotte Sandersen, François Delvaux, Elise Mercier, Myrielle Mathieu, Kathleen Mc Entee |
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| Rok vydání: | 2010 |
| Předmět: |
Aging
Cardiac Catheterization medicine.medical_specialty Cardiac output Systole Blood viscosity Hemodynamics Blood Pressure Pulmonary Artery Doppler echocardiography Doppler imaging Dogs Respiratory Rate Diastole Heart Rate Reference Values Internal medicine medicine Animals Anthelmintics General Veterinary medicine.diagnostic_test business.industry Patient Selection Stroke Volume Blood Proteins General Medicine Blood flow Blood Viscosity Echocardiography Doppler medicine.anatomical_structure Blood pressure Vascular resistance Cardiology Vascular Resistance business |
| Zdroj: | American Journal of Veterinary Research. 71:891-897 |
| ISSN: | 0002-9645 |
| DOI: | 10.2460/ajvr.71.8.891 |
| Popis: | Objective—To assess the influence of age on pulmonary hemodynamics and hemorheological properties in healthy dogs. Animals—14 healthy Beagles. Procedures—Dogs were placed in 2 age groups as follows: young dogs (≤ 5 years old; n = 8) and old dogs (≥ 8 years old; 6). Hematologic characteristics, plasma total protein and fibrinogen concentrations, and blood viscosity were measured. Systolic time intervals of pulmonary blood flow were recorded by pulsed-wave Doppler echocardiography. Early (E′) and late (A′) diastolic myocardial velocities, isovolumic contraction velocity, and systolic myocardial velocity of the free tricuspid annulus were recorded by pulsed-wave tissue Doppler imaging (TDI). Dogs were anesthetized and pulmonary arterial pressures (PAP) and cardiac output were recorded with a pediatric thermodilution Swan-Ganz catheter. Results—Hemorheological measurements were not different between the 2 groups. Systolic, mean, and diastolic PAP were higher in old dogs, compared with values in young dogs; this difference was attributed to a high pulmonary vascular resistance and low arterial compliance in old dogs. Systolic time intervals of pulmonary blood flow stayed unchanged. The A′ wave of the free tricuspid annulus was increased in old, compared with that young dogs, and the E′:A′ ratio was decreased. Pulmonary vascular resistance was inversely correlated with compliance. Conclusions and Clinical Relevance—The age of dogs should be taken into account when interpreting pulmonary hemodynamic results and TDI variables of right ventricular diastolic function. |
| Databáze: | OpenAIRE |
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