Transplantation of micro- and macroencapsulated piglet islets into mice and monkeys
| Autor: | R B. Elliott, G. Basta, O. Garkavenko, L. Escobar, Riccardo Calafiore, Clare Bambra, A.V. Vasconcellos |
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| Rok vydání: | 2005 |
| Předmět: |
medicine.medical_specialty
Swine Xenotransplantation medicine.medical_treatment Transplantation Heterologous Islets of Langerhans Transplantation Endogenous retrovirus Capsules Nod Biology Mice Mice Inbred NOD Internal medicine Diabetes mellitus medicine Animals Transplantation geography geography.geographical_feature_category Porcine islets Islet medicine.disease Macaca fascicularis Diabetes Mellitus Type 1 Endocrinology Surgery |
| Zdroj: | Transplantation Proceedings. 37:466-469 |
| ISSN: | 0041-1345 |
| Popis: | Neonatal porcine islets within alginate microcapsules transplanted intraperitoneally (IP) or within semi-permeable macrocapsules (TheraCyte) and transplanted subcutaneously (SC) survive and reverse diabetes for up to 16 weeks in diabetic autoimmune nonobese diabetic (NOD) mice. The islets in microcapsules transplanted IP into nondiabetic cynomolgus monkeys survived for 8 weeks. Similar results were shown with islets transplanted in TheraCytes. Neither species showed adverse effects or evidence of infection with porcine endogenous retroviruses or other endemic pig viruses. Proof of principle is illustrated for successful xenotransplantation in humans. |
| Databáze: | OpenAIRE |
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