Quantitative Dual-Energy Computed Tomography Supports a Vascular Etiology of Smoking-induced Inflammatory Lung Disease
| Autor: | John D. Newell, Matthew K. Fuld, Punam K. Saha, Krishna S. Iyer, Sif Hansdottir, Eric A. Hoffman, Dakai Jin |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Adult
Male Pulmonary and Respiratory Medicine medicine.medical_specialty Pathology Endothelium Sildenafil Blood volume Critical Care and Intensive Care Medicine 030218 nuclear medicine & medical imaging Pulmonary function testing Radiography Dual-Energy Scanned Projection 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Internal medicine medicine Humans Endothelial dysfunction Lung COPD business.industry Smoking Blood flow Middle Aged medicine.disease respiratory tract diseases medicine.anatomical_structure Pulmonary Emphysema 030228 respiratory system chemistry Cardiology Original Article Female Endothelium Vascular Tomography X-Ray Computed business |
| Zdroj: | American Journal of Respiratory and Critical Care Medicine. 193:652-661 |
| ISSN: | 1535-4970 1073-449X |
| DOI: | 10.1164/rccm.201506-1196oc |
| Popis: | Endothelial dysfunction is of interest in relation to smoking-associated emphysema, a component of chronic obstructive pulmonary disease (COPD). We previously demonstrated that computed tomography (CT)-derived pulmonary blood flow (PBF) heterogeneity is greater in smokers with normal pulmonary function tests (PFTs) but who have visual evidence of centriacinar emphysema (CAE) on CT.We introduced dual-energy CT (DECT) perfused blood volume (PBV) as a PBF surrogate to evaluate whether the CAE-associated increased PBF heterogeneity is reversible with sildenafil.Seventeen PFT-normal current smokers were divided into CAE-susceptible (SS; n = 10) and nonsusceptible (NS; n = 7) smokers, based on the presence or absence of CT-detected CAE. DECT-PBV images were acquired before and 1 hour after administration of 20 mg oral sildenafil. Regional PBV and PBV coefficients of variation (CV), a measure of spatial blood flow heterogeneity, were determined, followed by quantitative assessment of the central arterial tree.After sildenafil administration, regional PBV-CV decreased in SS subjects but did not decrease in NS subjects (P0.05), after adjusting for age and pack-years. Quantitative evaluation of the central pulmonary arteries revealed higher arterial volume and greater cross-sectional area (CSA) in the lower lobes of SS smokers, which suggested arterial enlargement in response to increased peripheral resistance. After sildenafil, arterial CSA decreased in SS smokers but did not decrease in NS smokers (P0.01).These results demonstrate that sildenafil restores peripheral perfusion and reduces central arterial enlargement in normal SS subjects with little effect in NS subjects, highlighting DECT-PBV as a biomarker of reversible endothelial dysfunction in smokers with CAE. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|