The pleiotrophin-ALK axis is required for tumorigenicity of glioblastoma stem cells
| Autor: | R Haruta, Yasushi Ino, E Manabe, M Matsui, Katsuhiko Shirahige, Nobuhito Saito, H Sugano, Kosuke Funato, Yuki Katou, Akitake Mukasa, Kenzui Taniue, Tomoki Todo, A Hoshino-Okubo, Yukiko Nasu-Nishimura, Ryota Takahashi, Tetsu Akiyama, Ryo Koyama-Nasu |
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| Rok vydání: | 2013 |
| Předmět: |
Transcriptional Activation
Cancer Research Carcinogenesis Mice Nude Biology Pleiotrophin Mice SOX2 hemic and lymphatic diseases Tumor Cells Cultured Genetics Animals Humans Anaplastic lymphoma kinase Anaplastic Lymphoma Kinase Progenitor cell Molecular Biology Transcription factor Cell Proliferation Mice Inbred BALB C Brain Neoplasms SOXB1 Transcription Factors HEK 293 cells Receptor Protein-Tyrosine Kinases Neural stem cell Gene Expression Regulation Neoplastic HEK293 Cells Neoplastic Stem Cells Cancer research Cytokines Stem cell Carrier Proteins Glioblastoma Neoplasm Transplantation |
| Zdroj: | Oncogene. 33:2236-2244 |
| ISSN: | 1476-5594 0950-9232 |
| Popis: | Increasing evidence suggests that brain tumors arise from the transformation of neural stem/precursor/progenitor cells. Much current research on human brain tumors is focused on the stem-like properties of glioblastoma. Here we show that anaplastic lymphoma kinase (ALK) and its ligand pleiotrophin are required for the self-renewal and tumorigenicity of glioblastoma stem cells (GSCs). Furthermore, we demonstrate that pleiotrophin is transactivated directly by SOX2, a transcription factor essential for the maintenance of both neural stem cells and GSCs. We speculate that the pleiotrophin-ALK axis may be a promising target for the therapy of glioblastoma. |
| Databáze: | OpenAIRE |
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