Zinc and diabetes mellitus: understanding molecular mechanisms and clinical implications
| Autor: | Godwin R Constantine, Priyadarshani Galappatthy, Prasad Katulanda, Shehani Pigera, Priyanga Ranasinghe |
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| Jazyk: | angličtina |
| Předmět: |
medicine.medical_treatment
MEDLINE Review Article Pharmacology Bioinformatics Antioxidants Pathogenesis Islets of Langerhans Diabetes mellitus Animals Humans Medicine Glucose homeostasis Prediabetes business.industry Mechanism (biology) Insulin Building and Construction Lipid Metabolism medicine.disease Clinical trial Zinc Diabetes Mellitus Type 1 Diabetes Mellitus Type 2 Carbohydrate Metabolism business |
| Zdroj: | DARU Journal of Pharmaceutical Sciences |
| ISSN: | 2008-2231 |
| DOI: | 10.1186/s40199-015-0127-4 |
| Popis: | Background Diabetes mellitus is a leading cause of morbidity and mortality worldwide. Studies have shown that Zinc has numerous beneficial effects in both type-1 and type-2 diabetes. We aim to evaluate the literature on the mechanisms and molecular level effects of Zinc on glycaemic control, β-cell function, pathogenesis of diabetes and its complications. Methods A review of published studies reporting mechanisms of action of Zinc in diabetes was undertaken in PubMed and SciVerse Scopus medical databases using the following search terms in article title, abstract or keywords; (“Zinc” or “Zn”) and (“mechanism” or “mechanism of action” or “action” or “effect” or “pathogenesis” or “pathology” or “physiology” or “metabolism”) and (“diabetes” or “prediabetes” or “sugar” or “glucose” or “insulin”). Results The literature search identified the following number of articles in the two databases; PubMed (n = 1799) and SciVerse Scopus (n = 1879). After removing duplicates the total number of articles included in the present review is 111. Our results show that Zinc plays an important role in β-cell function, insulin action, glucose homeostasis and the pathogenesis of diabetes and its complications. Conclusion Numerous in-vitro and in-vivo studies have shown that Zinc has beneficial effects in both type-1 and type-2 diabetes. However further randomized double-blinded placebo-controlled clinical trials conducted for an adequate duration, are required to establish therapeutic safety in humans. Electronic supplementary material The online version of this article (doi:10.1186/s40199-015-0127-4) contains supplementary material, which is available to authorized users. |
| Databáze: | OpenAIRE |
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