Differential expression of FCRLA in naïve and activated mouse B cells
| Autor: | Evdokiya S. Reshetnikova, Chikaev Na, Peter D. Burrows, Sergey V. Guselnikov, Olga Y. Volkova, Boris Y. Alabyev, Ludmila V. Mechetina, Alexander M. Najakshin, Dorottya Kövesdi, Gabriella Sármay, Alexander V. Taranin |
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| Rok vydání: | 2012 |
| Předmět: |
Lymphoid Tissue
Cellular differentiation Immunology Immunoglobulins Lymphocyte Activation Antibodies Article Mice Bone Marrow medicine Animals Secretion Receptors Immunologic Receptor B cell B-Lymphocytes Mice Inbred BALB C biology Intracellular Signaling Peptides and Proteins Cell Differentiation Marginal zone Molecular biology Cell biology medicine.anatomical_structure Mice Inbred CBA biology.protein Female Antibody Signal transduction Intracellular Signal Transduction |
| Zdroj: | Cellular Immunology. 272:182-192 |
| ISSN: | 0008-8749 |
| DOI: | 10.1016/j.cellimm.2011.10.013 |
| Popis: | FCRLA is an intracellular B cell protein that belongs to the FcR-like family. Using newly generated FCRLA-specific antibodies, we studied the constitutive expression pattern of mouse FCRLA and monitored changes during an immune response and following in vitro B cell activation. All B cell subpopulations examined expressed FCRLA. However, the level of FCRLA expression is determined by the stage of B cell differentiation. Low expression of FCRLA is characteristic of naïve follicular and marginal zone B cells. High expression was detected in a small fraction of activated B cells scattered along migratory pathways in the lymphoid tissues. FCRLA-bright cells could be subdivided into two subpopulations, with high and low/undetectable level of intracellular immunoglobulins, which phenotypically resemble either plasma or memory B cells. High expression of FCRLA in subset(s) of terminally differentiated B-cells suggests that, being an ER protein, FCRLA may participate in the regulation of immunoglobulin assembly and secretion. |
| Databáze: | OpenAIRE |
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