Angiopoietin-like protein 6 in patients with obesity, type 2 diabetes mellitus, and anorexia nervosa: The influence of very low-calorie diet, bariatric surgery, and partial realimentation
| Autor: | Denisa Haluzikova, P Kaválková, Mikulas Kosak, Milos Mraz, Hana Papezova, Z Lacinová, Martin Haluzik, Anna Cinkajzlová, Jana Klouckova, P Trachta |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Anorexia Nervosa food.diet Bariatric Surgery Energy homeostasis 03 medical and health sciences 0302 clinical medicine Endocrinology food Angiopoietin-like Protein Internal medicine medicine Humans In patient Angiopoietin-Like Protein 6 Obesity Caloric Restriction business.industry Type 2 Diabetes Mellitus General Medicine Middle Aged medicine.disease Surgery Very low calorie diet Angiopoietin-like Proteins Treatment Outcome 030104 developmental biology Diabetes Mellitus Type 2 Anorexia nervosa (differential diagnoses) 030220 oncology & carcinogenesis business Angiopoietins Body mass index |
| Zdroj: | Endocrine Research. 42:22-30 |
| ISSN: | 1532-4206 0743-5800 |
| DOI: | 10.3109/07435800.2016.1169544 |
| Popis: | Angiopoietin-like protein 6 (ANGPTL6) is a circulating protein with a potential role in energy homeostasis. The aim of the study was to explore the changes in ANGPTL6 levels in patients with obesity (Body mass index, BMI40 kg/mThe study included 23 non-diabetic obese patients, 40 obese patients with T2DM (27 underwent VLCD and 13 underwent bariatric surgery), 22 patients with AN, and 37 healthy control subjects.ANGPTL6 levels of AN patients were increased relative to the control group (68.6 ± 9.9 ng/ml) and decreased from 110.2 ± 13.3 to 73.6 ± 7.1 ng/ml (p = 0.004) after partial realimentation. Baseline ANGPTL6 levels in patients with obesity and T2DM did not differ from the control group. VLCD decreased ANGPTL6 levels only in obese patients with T2DM. Bariatric surgery induced a transient elevation of ANGPTL6 levels with a subsequent decrease to baseline levels. ANGPTL6 mRNA expression transiently increased after bariatric surgery and returned to baseline levels after 12 months.Collectively, our data suggest that serum ANGPTL6 levels and ANGPTL6 mRNA expression in SAT are affected by metabolic disorders and their treatment but do not appear to directly reflect nutritional status. |
| Databáze: | OpenAIRE |
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