Increased prefrontal top-down control in older adults predicts motor performance and age-group association
| Autor: | Marc Tittgemeyer, Immo Weber, Felix Sebastian Nettersheim, Lars Timmermann, Fabienne Homberg, Carina R. Oehrn, Philipp Alexander Loehrer |
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| Rok vydání: | 2021 |
| Předmět: |
Adult
Male medicine.medical_specialty Cognitive Neuroscience Dynamic Causal Modelling (DCM) Prefrontal Cortex Neurosciences. Biological psychiatry. Neuropsychiatry Premotor Areas Electroencephalography Healthy Aging Young Adult Physical medicine and rehabilitation medicine Humans Electroencephalography (EEG) Control (linguistics) Bimanual coordination Association (psychology) Movement preparation Preparatory phase Aged Cortical atrophy medicine.diagnostic_test Dynamic causal modelling Age Factors Motor control Middle Aged Ageing Neurology Potential biomarkers Female Healthy ageing Psychology Photic Stimulation Psychomotor Performance RC321-571 Forecasting |
| Zdroj: | NeuroImage, Vol 240, Iss, Pp 118383-(2021) |
| ISSN: | 1053-8119 |
| DOI: | 10.1016/j.neuroimage.2021.118383 |
| Popis: | Bimanual motor control declines during healthy ageing, affecting the ability of older adults to maintain independence. Age-related changes in neural dynamics of movement preparation that underlie reduced bimanual motor control, however, remain largely elusive. Here, we assessed effective connectivity within a prefrontal-premotor network of 19 young and 20 older adults during the preparatory phase of complex bimanual movements using high-density electroencephalography and Dynamic Causal Modelling of evoked responses. We found that excitatory interhemispheric prefrontal to premotor coupling in older adults predicted age-group association and poor motor-performance. In contrast, excitatory intrahemispheric prefrontal to premotor coupling enabled older adults to maintain motor-performance at the cost of lower movement speed. Our results disentangle the complex interplay in the prefrontal-premotor network underlying reduced bimanual control and the well-known speed-accuracy trade-off seen in older adults. We anticipate these coupling patterns to be potential biomarkers for healthy ageing and a possible future target of non-invasive brain-stimulation. |
| Databáze: | OpenAIRE |
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