EVALUATION OF SURGICAL FACTORS AFFECTING VITREOUS HEMORRHAGE FOLLOWING PORT DELIVERY SYSTEM WITH RANIBIZUMAB IMPLANT INSERTION IN A MINIPIG MODEL

Autor: Jay M. Stewart, Joshua Horvath, Vladimir Bantseev, T Michael Nork, Chris Schuetz, Ellison Bentley, William R. Freeman, Helen Booler, Kristof Hovaten, Signe Erickson, Giulio Barteselli
Rok vydání: 2020
Předmět:
Male
Vascular Endothelial Growth Factor A
genetic structures
Swine
medicine.medical_treatment
Visual Acuity
Angiogenesis Inhibitors
Fundus (eye)
Ophthalmology & Optometry
0302 clinical medicine
Drug Delivery Systems
animal surgical model
Homeostasis
Original Study
Drug Implants
0303 health sciences
General Medicine
Dissection
medicine.anatomical_structure
Cauterization
Swine
Miniature
Sclera
medicine.drug
Pars plana
medicine.medical_specialty
03 medical and health sciences
Opthalmology and Optometry
Ophthalmology
Ranibizumab
medicine
Animals
anti-vascular endothelial growth factor
Intraocular Pressure
Port Delivery System
030304 developmental biology
vitreous hemorrhage
business.industry
Diathermy
medicine.disease
eye diseases
Vitreous Body
Disease Models
Animal
Vitreous hemorrhage
030221 ophthalmology & optometry
anti–vascular endothelial growth factor
Implant
sense organs
retinal disease
business
Follow-Up Studies
Zdroj: Retina (Philadelphia, Pa.), vol 40, iss 8
Retina (Philadelphia, Pa.)
Popis: Supplemental Digital Content is Available in the Text. This minipig model of vitreous hemorrhage demonstrated that scleral dissection followed by thorough laser ablation of the pars plana before the pars plana incision could mitigate vitreous hemorrhage during Port Delivery System with ranibizumab implant insertion surgery.
Purpose: To develop an animal model of vitreous hemorrhage (VH) to explore the impact of surgical parameters on VH associated with insertion of the Port Delivery System with ranibizumab (PDS) implant. Methods: Ninety eyes from 45 treatment-naive male Yucatan minipigs received PDS implant insertion or a sham procedure. The effect of prophylactic pars plana hemostasis, scleral incision length, scleral cauterization, surgical blade type/size, and viscoelastic usage on postsurgical VH was investigated. Results: Postsurgical VH was detected in 60.0% (54/90) of implanted eyes. A systematic effect on VH was only detected for pars plana hemostasis before the pars plana incision. The percentage of eyes with VH was 96.6% (28/29) among eyes that did not receive prophylactic pars plana hemostasis and 42.4% (24/58) among eyes that did. There was no VH in eyes that received laser ablation of the pars plana using overlapping 1,000-ms spots; pars plana cautery or diathermy was less effective. The majority of all VH cases (83.3% [45/54]) were of mild to moderate severity (involving ≤25% of the fundus). Conclusion: In this minipig surgical model of VH, scleral dissection followed by pars plana laser ablation before pars plana incision most effectively mitigated VH secondary to PDS implant insertion.
Databáze: OpenAIRE
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