Persistence of in vitro lymphocyte response to tuberculin skin test negative children immunized with BCG in infancy
| Autor: | E. Assif, M. Mendes, N. Bogair, J. Schwartz, V. Zakuth, Zvi Spirer |
|---|---|
| Rok vydání: | 1977 |
| Předmět: |
Skin reactivity
business.industry Tuberculin Test Lymphocyte Infant Newborn Tuberculin General Medicine Skin test bacterial infections and mycoses In vitro Thymidine incorporation Persistence (computer science) Vaccination medicine.anatomical_structure Pediatrics Perinatology and Child Health Immunology medicine BCG Vaccine Humans Lymphocytes business Child Tuberculosis Pulmonary |
| Zdroj: | Acta paediatrica Scandinavica. 66(5) |
| ISSN: | 0001-656X |
| Popis: | PPD stimulated lymphocyte reactivity was tested in 119 children aged 11 to 12 years. The lymphocyte responses was evaluated by measuring the extent of tritiated thymidine incorporation by cultured cells. In a group of sixty-four tuberculin negative children who had been BCG vaccinated in the neonatal period, lymphocyte response was significantly greater than in a group of non-vaccinated tuberculin negative children matched for sex. The highest reactivity appeared in another group of children vaccinated in infancy and tuberculin positive. Lymphocytes from BCG vaccinated children retain some sensitivity to tuberculin even years after the BCG vaccination and even at the time when the skin reactivity disappeared. |
| Databáze: | OpenAIRE |
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