Novel Imidazolium Salt–Peptide Conjugates and Their Antimicrobial Activity
| Autor: | Andre Reinhardt, Ines Neundorf, A. Schubert, Andreas Bröhl, Ralf Giernoth, Mareike Horn, C. Oelkrug, J. Pieper gen. Schmauck |
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| Rok vydání: | 2014 |
| Předmět: |
Methicillin-Resistant Staphylococcus aureus
Erythrocytes Antimicrobial peptides Biomedical Engineering Ionic Liquids Pharmaceutical Science Salt (chemistry) Bioengineering Peptide Microbial Sensitivity Tests Structure-Activity Relationship chemistry.chemical_compound Anti-Infective Agents Drug Resistance Bacterial Humans Organic chemistry Structure–activity relationship Solid-Phase Synthesis Techniques Pharmacology chemistry.chemical_classification Chemistry Organic Chemistry Imidazoles Antimicrobial Ionic liquid Salts Peptides Antibacterial activity Selectivity Biotechnology |
| Zdroj: | Bioconjugate Chemistry. 25:2166-2174 |
| ISSN: | 1520-4812 1043-1802 |
| Popis: | Our study presents innovative research dealing with the synthesis and biological evaluation of conjugates out of antimicrobial peptides (AMPs) and imidazolium cations that are derived from ionic liquids. AMPs are considered as promising alternatives to common antibiotics due to their different activity mechanisms. Antibacterial effects have also been described for ionic liquids bearing imidazolium cations . Besides single coupling of carboxy-functionalized imidazolium cations to the peptide N-terminal we also developed conjugates bearing multiple copies of imidazolium cations. The combination of both compounds resulted in synergistic effects that were most pronounced when more imidazolium cations were attached to the peptides. In addition, antibacterial activity even in drug-resistant bacterial strains could be observed. Moreover, the novel compounds showed good selectivity only against bacterial cells, an observation that was further proven by lipid interaction studies using giant unilamellar vesicles. |
| Databáze: | OpenAIRE |
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