Prostaglandin stimulation of canine platelet adenylate cyclase
| Autor: | Gene C. Palmer, S. Jo Palmer, Gesina L. Longenecker, Linda J. Kopaciewicz |
|---|---|
| Rok vydání: | 1980 |
| Předmět: |
Blood Platelets
medicine.medical_specialty Epinephrine GTP' medicine.medical_treatment Adenylate kinase Prostaglandin Stimulation Cyclase chemistry.chemical_compound Dogs Internal medicine medicine Animals heterocyclic compounds Platelet Guanylyl Imidodiphosphate Prostaglandins A Dose-Response Relationship Drug Prostaglandins E Prostaglandins F Hematology Endocrinology chemistry Prostaglandins lipids (amino acids peptides and proteins) Adenylyl Cyclases Prostaglandin E medicine.drug |
| Zdroj: | Thrombosis Research. 19:119-124 |
| ISSN: | 0049-3848 |
| DOI: | 10.1016/0049-3848(80)90410-7 |
| Popis: | Homogenates of washed canine platelets possessed an adenylate cyclase system that was potently activated by prostaglandin (PG) E 1 and to a lesser extent by PGE 2 , A 2 and F 2a . The effect of the PGs on adenylate cyclase were not augmented by the GTP analog, 5′-guanylyl imidodiphosphate. Moreover, 1 ′epinephrine, a stimulator of canine platelet aggregation induced by other agents, acted as a weak inhibitor of the adenylate cyclase. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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