Elevated plasma endothelin-1 and cytokine levels in children with severe acute respiratory distress syndrome
| Autor: | Steven H. Abman, Jeffery Griebel, Patricia L. Eells, Emily L. Dobyns |
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| Rok vydání: | 1999 |
| Předmět: |
Male
ARDS medicine.medical_specialty Colorado medicine.medical_treatment Disease Gastroenterology Statistics Nonparametric Internal medicine medicine Humans Interleukin 6 Respiratory Distress Syndrome Newborn Endothelin-1 Respiratory distress biology Interleukin-6 Tumor Necrosis Factor-alpha business.industry Respiratory disease Infant Newborn Infant Prognosis medicine.disease Survival Analysis Endothelin 1 Cytokine Child Preschool Pediatrics Perinatology and Child Health Immunology biology.protein Female Tumor necrosis factor alpha business Biomarkers Interleukin-1 |
| Zdroj: | The Journal of Pediatrics. 135:246-249 |
| ISSN: | 0022-3476 |
| Popis: | We performed serial measurements of plasma endothelin-1 and cytokine levels (interleukin-1, interleukin-6, and tumor necrosis factor-alpha) in 23 children with severe acute respiratory distress syndrome during their first 7 days of disease. We report plasma endothelin-1 and interleukin-6 levels are increased in patients with acute respiratory distress syndrome, and that plasma endothelin-1 levels are significantly greater early in the clinical course of nonsurvivors than survivors. We conclude that plasma endothelin-1 levels are markedly increased in children with severe acute respiratory distress syndrome and speculate that high levels may serve as an early marker of poor outcome. (J Pediatr 1999;135:246-9) |
| Databáze: | OpenAIRE |
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