Acute infection–inflammation and coronary stent thrombosis: an observational study
| Autor: | Gian Franco Gensini, Raffaele Rasoini, Rosanna Abbate, Maria Boddi, Stefano Del Pace, Serena Micheli, Camilla Alderighi, Sabina Caciolli, Massimo Margheri |
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| Rok vydání: | 2010 |
| Předmět: |
Male
medicine.medical_specialty medicine.medical_treatment Infections Ventricular Function Left Coronary Restenosis Coronary artery disease Coronary thrombosis Risk Factors Internal medicine Coronary stent Prevalence Internal Medicine medicine Humans Angioplasty Balloon Coronary Aged Retrospective Studies Aged 80 and over Inflammation Ejection fraction Interventional cardiology business.industry Coronary Thrombosis Stent Stroke Volume Retrospective cohort study Middle Aged medicine.disease Thrombosis Italy Acute Disease Emergency Medicine Cardiology Female Stents business human activities |
| Zdroj: | Internal and Emergency Medicine. 5:121-126 |
| ISSN: | 1970-9366 1828-0447 |
| Popis: | Coronary stent thrombosis (CST) is a major concern of interventional cardiology. Several risk factors for CST have been identified, but as a whole they do not explain the pathophysiology of CST. This study was designed to investigate whether acute infection-inflammation could facilitate the occurrence of CST. Forty-one patients, aged 66.6 +/- 11 years, consecutively admitted to our catheterization laboratory for acute, subacute or late CST, were retrospectively analysed. Transient acute infection-inflammation on admission for CST was diagnosed by predefined criteria. Prevalence of known risk factors for CST was also investigated. Twenty-one patients (51%) met predefined criteria for the occurrence of acute infection-inflammation. On admission, in these patients, levels of systemic humoral and cellular inflammatory markers were significantly higher than those of patients without recent or ongoing acute infection-inflammation (p0.05 for all). 62% of patients with acute infection-inflammation had less than two known risk factors for CST whereas only 37% patients without infection-inflammation showed less than two risk factors (p = 0.03) and showed more frequent interruption of antiplatelet treatment (17 vs. 2.4%, p = 0.02), mean longer stent length (20.5 +/- 4.8 vs. 16.5 +/- 5.1 mm, p = 0.02) and lower left ventricular ejection fraction before CST (42.9 +/- 14 vs. 47.3 +/- 11%, p = 0.02). In conclusion, acute infection-inflammation could play a role in facilitating the occurrence of CST in a subgroup with low risk profile for known risk factors. Our findings, if confirmed, could suggest new opportunities for prevention and treatment of CST. |
| Databáze: | OpenAIRE |
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