Targeting TR4 nuclear receptor suppresses prostate cancer invasion via reduction of infiltrating macrophages with alteration of the TIMP-1/MMP2/MMP9 signals

Autor:	Yuanjie Niu, Gonghui Li, Dong-Rong Yang, Shicheng Yu, Liqun Xia, Xianfan Ding, Bi-de Chen, Mingchao Wang, Chawnshang Chang
Rok vydání:	2015
Předmět:	Cancer Research MMP2 Biology urologic and male genital diseases medicine.disease 3. Good health Metastasis Prostate cancer Oncology Nuclear receptor Cancer research medicine Molecular Medicine Macrophage Signal transduction Receptor Foam cell
Zdroj:	Molecular Cancer. 14
ISSN:	1476-4598
DOI:	10.1186/s12943-014-0281-1
Popis:	Background TR4 nuclear receptor 4 (TR4) plays an important role in macrophages-associated foam cell formation of cardiovascular diseases and infiltrating macrophages are critical for prostate cancer (PCa) progression. However, the linkage of macrophages and TR4 and their impacts on PCa metastasis remains unclear.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e0214e391bb46ede4c63303272ba688 https://doi.org/10.1186/s12943-014-0281-1 Zobrazit plný text záznamu Full text from SpringerLink