Human immunoglobulin G levels of viruses and associated glioma risk
| Autor: | Jonas Manjer, Göran Wadell, Per Juto, Martin Almquist, Sara Sjöström, Jytte Halkjær, Göran Hallmans, Ulf Hjalmars, Anne Tjønneland, Beatrice Melin |
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| Rok vydání: | 2011 |
| Předmět: |
Adult
Male Epstein-Barr Virus Infections Herpesvirus 3 Human Herpesvirus 4 Human Cancer Research Case–control study Adenoviridae Infections viruses Population Cytomegalovirus Antibodies Viral Herpes Zoster Article Immunoglobulin G Virus Adenoviridae Cohort Studies Antigen Risk Factors Glioma Odds Ratio Humans Medicine education Aged education.field_of_study biology Brain Neoplasms business.industry Antigens Nuclear Odds ratio Middle Aged medicine.disease Oncology Case-Control Studies Cytomegalovirus Infections Immunology biology.protein Female Antibody Glioblastoma business Blood sampling |
| Zdroj: | Cancer Causes & Control |
| ISSN: | 1573-7225 0957-5243 |
| Popis: | Few consistent etiological factors have been identified for primary brain tumors. Inverse associations to asthma and low levels of varicella-zoster virus, immunoglobulin (Ig) levels in prevalent cases have indicted a role for the immune system in the development of glioma. Because samples from prevalent cases of glioma could be influenced by treatments such as steroids and chemotherapy, we investigated pre-diagnostic samples from three large Scandinavian cohorts. To test the hypothesis that immune response levels to these viruses are associated etiologically with glioma risk, we investigated pre-diagnostic immunoglobulin levels for cytomegalovirus (CMV), varicella-zoster virus (VZV), adenovirus (Ad), and Epstein-Barr virus (EBV) including the nuclear antigen (EBNA1) using plasma samples from 197 cases of adult glioma and 394 controls collected from population-based cohorts in Sweden and Denmark. Low VZV IgG levels were marginally significantly more common in glioma cases than the controls (odds ratio (OR) = 0.68, 95% CI 0.41-1.13) for the fourth compared with the first quartile (p = 0.06 for trend). These results were more prominent when analyzing cases with blood sampling at least 2 years before diagnosis (OR = 0.63, 95% CI 0.37-1.08) (p = 0.03). No association with glioma risk was observed for CMV, EBV, and adenovirus. |
| Databáze: | OpenAIRE |
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