Matrix metalloproteinases inhibitors in idiopathic pulmonary fibrosis: Medicinal chemistry perspectives
| Autor: | Xingping Su, Tinghong Ye, Lin Yue, Guan Wang, Liang Ouyang, Yaojie Shi |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Pharmacology
Models Molecular Poor prognosis MMP Inhibitors Chemistry Chemistry Pharmaceutical Organic Chemistry General Medicine Disease respiratory system Matrix metalloproteinase Matrix Metalloproteinase Inhibitors Bleomycin medicine.disease Prognosis humanities Idiopathic Pulmonary Fibrosis respiratory tract diseases chemistry.chemical_compound Idiopathic pulmonary fibrosis Drug Discovery Cancer research medicine Humans |
| Zdroj: | European journal of medicinal chemistry. 224 |
| ISSN: | 1768-3254 |
| Popis: | Idiopathic pulmonary fibrosis (IPF) is a lethal disease with limited therapeutic options and a particularly poor prognosis. Matrix metalloproteinases (MMPs), promising targets for the treatment of IPF, have been identified as playing a pivotal role in IPF. Although the pathological processes of MMPs and IPF have been verified, there are no MMP inhibitors for the treatment of IPF in the clinic. In this review, we will present the latest developments in MMP inhibitors, including pharmacophores, binding modes, selectivity and optimization strategies. In addition, we will also discuss the future development direction of MMP inhibitors based on emerging tools and techniques. |
| Databáze: | OpenAIRE |
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