Cellular and Intercellular Homeostasis in Adipose Tissue with Mitochondria-Specific Stress
| Autor: | Minho Shong, Min Jeong Choi, Joon Young Chang, Saet-Byel Jung |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Namgok Lecture 2020
Adipose Tissue White Endocrinology Diabetes and Metabolism adipocytes Adipose tissue Cellular homeostasis 030209 endocrinology & metabolism White adipose tissue Mitochondrion Biology lcsh:Diseases of the endocrine glands. Clinical endocrinology 03 medical and health sciences Paracrine signalling 0302 clinical medicine Endocrinology Intracellular organelle Mitochondrial unfolded protein response energy metabolism Homeostasis Humans lcsh:RC648-665 unfolded protein response Cell biology macrophages mitochondria Adipose Tissue 030220 oncology & carcinogenesis Unfolded protein response |
| Zdroj: | Endocrinology and Metabolism, Vol 36, Iss 1, Pp 1-11 (2021) Endocrinology and Metabolism |
| ISSN: | 2093-5978 |
| Popis: | Paracrine interactions are imperative for the maintenance of adipose tissue intercellular homeostasis, and intracellular organelle dysfunction results in local and systemic alterations in metabolic homeostasis. It is currently accepted that mitochondrial proteotoxic stress activates the mitochondrial unfolded protein response (UPRmt) in vitro and in vivo. The induction of mitochondrial chaperones and proteases during the UPRmt is a key cell-autonomous mechanism of mitochondrial quality control. The UPRmt also affects systemic metabolism through the secretion of cell non-autonomous peptides and cytokines (hereafter, metabokines). Mitochondrial function in adipose tissue plays a pivotal role in whole-body metabolism and human diseases. Despite continuing interest in the role of the UPRmt and quality control pathways of mitochondria in energy metabolism, studies on the roles of the UPRmt and metabokines in white adipose tissue are relatively sparse. Here, we describe the role of the UPRmt in adipose tissue, including adipocytes and resident macrophages, and the interactive roles of cell non-autonomous metabokines, particularly growth differentiation factor 15, in local adipose cellular homeostasis and systemic energy metabolism. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|