Endothelial Dysfunction, Inflammation and Coronary Artery Disease: Potential Biomarkers and Promising Therapeutical Approaches

Autor: Mayra Domínguez-Pérez, Teresa Villarreal-Molina, Diana Jhoseline Medina-Leyte, Antonia González-Garrido, Oscar Zepeda-García, Leonor Jacobo-Albavera
Rok vydání: 2021
Předmět:
0301 basic medicine
Review
Coronary Artery Disease
030204 cardiovascular system & hematology
Bioinformatics
endothelial dysfunction
Coronary artery disease
lcsh:Chemistry
0302 clinical medicine
endothelial cells (EC)
therapeutics
Molecular Targeted Therapy
Endothelial dysfunction
lcsh:QH301-705.5
Spectroscopy
Cause of death
Disease Management
General Medicine
Pathophysiology
Computer Science Applications
Vascular endothelium
medicine.anatomical_structure
Disease Susceptibility
medicine.symptom
Vasculitis
Endothelium
endothelium
Inflammation
Catalysis
Inorganic Chemistry
Capillary Permeability
03 medical and health sciences
coronary artery disease (CAD)
medicine
Animals
Humans
Physical and Theoretical Chemistry
Molecular Biology
Hemostasis
business.industry
Organic Chemistry
medicine.disease
novel biomarkers
030104 developmental biology
lcsh:Biology (General)
lcsh:QD1-999
inflammation
Potential biomarkers
Endothelium
Vascular
atherosclerosis
business
Biomarkers
Zdroj: International Journal of Molecular Sciences, Vol 22, Iss 3850, p 3850 (2021)
International Journal of Molecular Sciences
ISSN: 1422-0067
Popis: Coronary artery disease (CAD) and its complications are the leading cause of death worldwide. Inflammatory activation and dysfunction of the endothelium are key events in the development and pathophysiology of atherosclerosis and are associated with an elevated risk of cardiovascular events. There is great interest to further understand the pathophysiologic mechanisms underlying endothelial dysfunction and atherosclerosis progression, and to identify novel biomarkers and therapeutic strategies to prevent endothelial dysfunction, atherosclerosis and to reduce the risk of developing CAD and its complications. The use of liquid biopsies and new molecular biology techniques have allowed the identification of a growing list of molecular and cellular markers of endothelial dysfunction, which have provided insight on the molecular basis of atherosclerosis and are potential biomarkers and therapeutic targets for the prevention and or treatment of atherosclerosis and CAD. This review describes recent information on normal vascular endothelium function, as well as traditional and novel potential biomarkers of endothelial dysfunction and inflammation, and pharmacological and non-pharmacological therapeutic strategies aimed to protect the endothelium or reverse endothelial damage, as a preventive treatment for CAD and related complications.
Databáze: OpenAIRE
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