Endothelial Dysfunction, Inflammation and Coronary Artery Disease: Potential Biomarkers and Promising Therapeutical Approaches
Autor: | Mayra Domínguez-Pérez, Teresa Villarreal-Molina, Diana Jhoseline Medina-Leyte, Antonia González-Garrido, Oscar Zepeda-García, Leonor Jacobo-Albavera |
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Rok vydání: | 2021 |
Předmět: |
0301 basic medicine
Review Coronary Artery Disease 030204 cardiovascular system & hematology Bioinformatics endothelial dysfunction Coronary artery disease lcsh:Chemistry 0302 clinical medicine endothelial cells (EC) therapeutics Molecular Targeted Therapy Endothelial dysfunction lcsh:QH301-705.5 Spectroscopy Cause of death Disease Management General Medicine Pathophysiology Computer Science Applications Vascular endothelium medicine.anatomical_structure Disease Susceptibility medicine.symptom Vasculitis Endothelium endothelium Inflammation Catalysis Inorganic Chemistry Capillary Permeability 03 medical and health sciences coronary artery disease (CAD) medicine Animals Humans Physical and Theoretical Chemistry Molecular Biology Hemostasis business.industry Organic Chemistry medicine.disease novel biomarkers 030104 developmental biology lcsh:Biology (General) lcsh:QD1-999 inflammation Potential biomarkers Endothelium Vascular atherosclerosis business Biomarkers |
Zdroj: | International Journal of Molecular Sciences, Vol 22, Iss 3850, p 3850 (2021) International Journal of Molecular Sciences |
ISSN: | 1422-0067 |
Popis: | Coronary artery disease (CAD) and its complications are the leading cause of death worldwide. Inflammatory activation and dysfunction of the endothelium are key events in the development and pathophysiology of atherosclerosis and are associated with an elevated risk of cardiovascular events. There is great interest to further understand the pathophysiologic mechanisms underlying endothelial dysfunction and atherosclerosis progression, and to identify novel biomarkers and therapeutic strategies to prevent endothelial dysfunction, atherosclerosis and to reduce the risk of developing CAD and its complications. The use of liquid biopsies and new molecular biology techniques have allowed the identification of a growing list of molecular and cellular markers of endothelial dysfunction, which have provided insight on the molecular basis of atherosclerosis and are potential biomarkers and therapeutic targets for the prevention and or treatment of atherosclerosis and CAD. This review describes recent information on normal vascular endothelium function, as well as traditional and novel potential biomarkers of endothelial dysfunction and inflammation, and pharmacological and non-pharmacological therapeutic strategies aimed to protect the endothelium or reverse endothelial damage, as a preventive treatment for CAD and related complications. |
Databáze: | OpenAIRE |
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