MRI evaluation of asymmetry of nigrostriatal damage in the early stage of early-onset Parkinson's disease
| Autor: | Jianli Wang, Thyagarajan Subramanian, Qing X. Yang, Jonathan Chu, Xiaoyu Sun, Zachary Mosher, Megha Vasavada, Jeffrey Vesek, Vikram Shivkumar, Kala Venkiteswaran, Sangam Kanekar |
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| Rok vydání: | 2014 |
| Předmět: |
Adult
Male medicine.medical_specialty Parkinson's disease Early onset Parkinson's disease Substantia nigra Motor Activity Functional Laterality Internal medicine Fractional anisotropy medicine Humans Stage (cooking) Putamen Neurodegeneration Parkinson Disease Middle Aged medicine.disease Substantia Nigra Diffusion Tensor Imaging Early Diagnosis nervous system Neurology Anesthesia Cardiology Female Neurology (clinical) Geriatrics and Gerontology Psychology Diffusion MRI |
| Zdroj: | Parkinsonismrelated disorders. 21(6) |
| ISSN: | 1873-5126 |
| Popis: | Introduction: The motor symptoms and signs of early-onset idiopathic Parkinson's disease (PD) in Hoehn and Yahr (H&Y) stage-1 are generally unilateral. We hypothesized that there would be detectable differences in the quantitative MRI parameters in these PD patients between the hemispheres contralateral to the clinically symptomatic and non-symptomatic body side. Methods: We tested this hypothesis by comparing transverse relaxation rates and diffusion tensor imaging (DTI) parameters in the substantia nigra and putamen between the two hemispheres contralateral to the symptomatic and non-symptomatic side in H&Y stage-1 PD patients who had onset of symptoms between ages of 40e59 years. Results: There were quantifiable hemispheric asymmetries in transverse relaxation rates in the substantia nigra, as well as fractional anisotropy and mean diffusivity in the putamen in early PD, which correlated with the unilaterality of motor symptoms as evaluated using the motor portion of the Unified Parkinson's Disease Rating Scale. Conclusion: Transverse relaxation mapping and DTI demonstrated significant differences between the symptomatic and non-symptomatic hemispheres at the early stage of early-onset PD. These findings support the hypothesis of asymmetric neurodegeneration in the bilateral nigrostriatal pathways in the early stage of the disease. |
| Databáze: | OpenAIRE |
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