Severity of depression and anxiety are predictors of response to antidepressant treatment in Parkinson's disease
| Autor: | Anke Wijers, Carlos Singer, C. Serrano Ramos, Chadwick W. Christine, Irene H. Richard, Michel Panisset, Peggy Auinger, Albert F.G. Leentjens, William M. McDonald, Jeffrey M. Lyness, Laura Marsh, Jorge J. Juncos, Anja J.H. Moonen, Stewart A. Factor, Lisa M. Shulman, John T. Slevin, Ronald F. Pfeiffer, David A. Rottenberg |
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| Přispěvatelé: | Promovendi MHN, MUMC+: MA Med Staf Spec Psychiatrie (9), Psychiatrie & Neuropsychologie, RS: MHeNs - R1 - Cognitive Neuropsychiatry and Clinical Neuroscience |
| Rok vydání: | 2014 |
| Předmět: |
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medicine.medical_specialty Parkinson's disease Datasets as Topic Venlafaxine Anxiety Placebo Severity of Illness Index Double-Blind Method Predictive Value of Tests Rating scale Internal medicine medicine Humans Depression (differential diagnoses) Aged Randomized Controlled Trials as Topic Psychiatric Status Rating Scales Depression Venlafaxine Hydrochloride Clinical trials randomized controlled Parkinson Disease Middle Aged Cyclohexanols medicine.disease Paroxetine Antidepressive Agents Neurology Antidepressant Female Neurology (clinical) Geriatrics and Gerontology medicine.symptom Psychology Follow-Up Studies Clinical psychology medicine.drug |
| Zdroj: | Parkinsonism & Related Disorders, 20(6), 644-646. ELSEVIER SCI LTD |
| ISSN: | 1353-8020 |
| DOI: | 10.1016/j.parkreldis.2014.02.025 |
| Popis: | Background Antidepressants have appeared to be more effective than placebo treatment in treating depressive syndromes in patients with Parkinson's disease (PD). Objective To identify factors that predict improvement in depressive symptoms during antidepressant treatment in depressed PD patients. Methods A secondary analysis was performed on the dataset of the Randomized Placebo-controlled Study of Antidepressants in PD (SAD-PD), in which 76 patients received active treatment with either paroxetine or venlafaxine extended release (XR), and 39 patients received placebo treatment. Backward stepwise regression analyses were conducted with change in 24-item Hamilton Depression Rating Scale (HAMD-24) score between assessments at baseline and week 12 as the main outcome measure, and sex, age, baseline HAMD-24 score, Unified Parkinson's Disease Rating Scale section III (UPDRS-III) score, Mini-Mental State Examination (MMSE), and the Clinical Anxiety Scale (CAS) as independent variables. Results In both the active treatment and placebo groups, higher baseline HAMD-24 score and lower UPDRS-III score were associated with greater reduction in HAMD-24 score. Higher anxiety scores predicted less response in the active treatment group. Higher MMSE scores predicted greater response only in the placebo-treated group. Sex and age were no predictors of response. Conclusions Higher pre-treatment depression scores and lower pre-treatment anxiety scores are the two most important predictors for improvement during antidepressant treatment in depressed PD patients, which is in line with those found in treatment studies of depressed non-PD patients. Furthermore, our results indicate the requirement for different or more intensive treatment for depressed PD patients with more severe anxiety symptoms. |
| Databáze: | OpenAIRE |
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