Optical Mapping-Validated Machine Learning Improves Atrial Fibrillation Driver Detection by Multi-Electrode Mapping
| Autor: | Dmitry V. Dylov, Katelynn M. Helfrich, Paul M.L. Janssen, Maxim V. Fedorov, Peter J. Mohler, Ekaterina Alekseevna Ivanova, Bryan A. Whitson, Alexander M. Zolotarev, John D. Hummel, Ning Li, Brian J. Hansen, Vadim V. Fedorov, Nahush A. Mokadam |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Time Factors
medicine.medical_treatment Action Potentials 030204 cardiovascular system & hematology Article Machine Learning 03 medical and health sciences 0302 clinical medicine Heart Rate Predictive Value of Tests Physiology (medical) Optical mapping Atrial Fibrillation Medicine Humans 030304 developmental biology 0303 health sciences Spectroscopy Near-Infrared Fourier Analysis business.industry Reproducibility of Results Atrial fibrillation medicine.disease Ablation Voltage-Sensitive Dye Imaging Electrode Cardiology and Cardiovascular Medicine business Electrophysiologic Techniques Cardiac Biomedical engineering |
| Zdroj: | Circ Arrhythm Electrophysiol |
| Popis: | Background:Atrial fibrillation (AF) can be maintained by localized intramural reentrant drivers. However, AF driver detection by clinical surface-only multielectrode mapping (MEM) has relied on subjective interpretation of activation maps. We hypothesized that application of machine learning to electrogram frequency spectra may accurately automate driver detection by MEM and add some objectivity to the interpretation of MEM findings.Methods:Temporally and spatially stable single AF drivers were mapped simultaneously in explanted human atria (n=11) by subsurface near-infrared optical mapping (NIOM; 0.3 mm2resolution) and 64-electrode MEM (higher density or lower density with 3 and 9 mm2resolution, respectively). Unipolar MEM and NIOM recordings were processed by Fourier transform analysis into 28 407 total Fourier spectra. Thirty-five features for machine learning were extracted from each Fourier spectrum.Results:Targeted driver ablation and NIOM activation maps efficiently defined the center and periphery of AF driver preferential tracks and provided validated annotations for driver versus nondriver electrodes in MEM arrays. Compared with analysis of single electrogram frequency features, averaging the features from each of the 8 neighboring electrodes, significantly improved classification of AF driver electrograms. The classification metrics increased when less strict annotation, including driver periphery electrodes, were added to driver center annotation. Notably, f1-score for the binary classification of higher-density catheter data set was significantly higher than that of lower-density catheter (0.81±0.02 versus 0.66±0.04,PConclusions:The machine learning model pretrained on Fourier spectrum features allows efficient classification of electrograms recordings as AF driver or nondriver compared with the NIOM gold-standard. Future application of NIOM-validated machine learning approach may improve the accuracy of AF driver detection for targeted ablation treatment in patients. |
| Databáze: | OpenAIRE |
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