Diagnostic model of saliva peptide finger print analysis of oral squamous cell carcinoma patients using weak cation exchange magnetic beads
| Autor: | Zhen Wang, Xin Peng, Li-Xin Xu, Wei-Peng Jiang, Feng Chen |
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| Rok vydání: | 2015 |
| Předmět: |
Male
Proteomics matrix-assisted laser-desorption ionization–time-of-flight–mass spectrometry (MALDI-TOF-MS) Saliva Biophysics Early detection Peptide Bioinformatics Peptide Mapping Biochemistry Diagnostic model Biomarkers Tumor Humans Basal cell Molecular Biology histatin-3 Histatin 3 Aged chemistry.chemical_classification Original Paper saliva Cell Biology Middle Aged Original Papers stomatognathic diseases chemistry oral squamous cell carcinoma (OSCC) Case-Control Studies Spectrometry Mass Matrix-Assisted Laser Desorption-Ionization Potential biomarkers Carcinoma Squamous Cell peptides Cancer research Female Mouth Neoplasms Finger print early diagnosis |
| Zdroj: | Bioscience Reports |
| ISSN: | 1573-4935 0144-8463 |
| DOI: | 10.1042/bsr20150023 |
| Popis: | Whole saliva (WS) was used for diagnosis of oral squamous cell carcinoma (OSCC); two polypeptides may be used for OSCC diagnosis. Saliva diagnostics utilizing nanotechnology and molecular technologies to detect oral squamous cell carcinoma (OSCC) has become an attractive field of study. However, no specific methods have been established. To refine the diagnostic power of saliva peptide fingerprints for the early detection of OSCC, we screened the expression spectrum of salivary peptides in 40 T1 stage OSCC patients (and healthy controls) using MALDI-TOF-MS combined with magnetic beads. Fifty proteins showed significantly different expression levels in the OSCC samples (P |
| Databáze: | OpenAIRE |
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