Diagnosis of breast cancer in women age 40 and younger: delays in diagnosis result from underuse of genetic testing and breast imaging
| Autor: | Srila Samphao, Kevin S. Hughes, Michelle C. Specht, Elizabeth A. Rafferty, Amanda J. Wheeler, Barbara L. Smith, James S. Michaelson, Michele A. Gadd |
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| Rok vydání: | 2009 |
| Předmět: |
Adult
medicine.medical_specialty Time Factors Digital mammography Breast imaging Breast Neoplasms Young Adult Breast cancer Humans Medicine Mammography Genetic Testing skin and connective tissue diseases Early Detection of Cancer Genetic testing Gynecology medicine.diagnostic_test business.industry BRCA mutation Age Factors Cancer General Medicine medicine.disease Magnetic Resonance Imaging Female Surgery Radiology Breast disease business |
| Zdroj: | The American Journal of Surgery. 198:538-543 |
| ISSN: | 0002-9610 |
| Popis: | Background The impact of newer breast imaging technologies and genetic testing on the detection of breast cancer in women age 40 and younger remains unknown. Methods A records review identified 628 women age 40 and younger diagnosed with breast cancer from 1996 to 2008. Patient and tumor characteristics, means of diagnosis, imaging results, and genetic testing were examined. Results Tumors were first detected by self-examination in 71%, with a median invasive tumor size of 2.0 cm. Imaging performed at or after diagnosis visualized most tumors; mammography visualized 86%, magnetic resonance imaging (MRI) visualized 96%, and mammography plus MRI visualized more than 98% of tumors. For 81% of patients, the mammogram at diagnosis was their first mammogram. Although 50% had a family history of breast or ovarian cancer, few underwent genetic testing before their cancer diagnosis; 61 of 247 (25%) ultimately tested had a BRCA mutation. Conclusions Better use of genetic testing, mammography, and MRI could improve breast cancer detection in young women. |
| Databáze: | OpenAIRE |
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