In vivo probe-based confocal laser endomicroscopy in amiodarone-related pneumonia
| Autor: | Geneviève Bourg-Heckly, Stéphane Dominique, Christine Vever-Bizet, Jean-Michel Vergnon, Vincent Jounieaux, Emmanuel Bergot, Francis Roussel, Mathieu Salaün, A. Genevois, Luc Thiberville, Gérard Zalcman |
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| Přispěvatelé: | Equipe Quantification en Imagerie Fonctionnelle (QuantIF-LITIS), Laboratoire d'Informatique, de Traitement de l'Information et des Systèmes (LITIS), Université Le Havre Normandie (ULH), Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Institut national des sciences appliquées Rouen Normandie (INSA Rouen Normandie), Institut National des Sciences Appliquées (INSA)-Normandie Université (NU)-Institut National des Sciences Appliquées (INSA)-Université Le Havre Normandie (ULH), Institut National des Sciences Appliquées (INSA)-Normandie Université (NU)-Institut National des Sciences Appliquées (INSA), Laboratoire Francis PERRIN (LFP - URA 2453), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Laboratoire Jean PERRIN, Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS), Institut de Mathématiques de Toulouse UMR5219 (IMT), Université Toulouse Capitole (UT Capitole), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Institut National des Sciences Appliquées (INSA)-Université de Toulouse (UT)-Institut National des Sciences Appliquées (INSA)-Université Toulouse - Jean Jaurès (UT2J), Université de Toulouse (UT)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS), Service de Pneumologie et Réanimation, CHU Amiens-Picardie, Centre de recherche clinique [CHU Caen] (CRC), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Tumorothèque de Caen Basse-Normandie (TCBN)-Centre Régional de Lutte contre le Cancer François Baclesse [Caen] (UNICANCER/CRLC), Normandie Université (NU)-UNICANCER-Tumorothèque de Caen Basse-Normandie (TCBN)-UNICANCER, Service de pneumologie [CHU Caen], Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Tumorothèque de Caen Basse-Normandie (TCBN), Institut national des sciences appliquées Rouen Normandie (INSA Rouen Normandie), Institut National des Sciences Appliquées (INSA)-Normandie Université (NU)-Institut National des Sciences Appliquées (INSA)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Université Le Havre Normandie (ULH), Normandie Université (NU), Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université Toulouse 1 Capitole (UT1), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Université Toulouse - Jean Jaurès (UT2J)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS), UNICANCER-Tumorothèque de Caen Basse-Normandie (TCBN)-Normandie Université (NU)-UNICANCER |
| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Male
Vasodilator Agents [SDV]Life Sciences [q-bio] Amiodarone MESH: Observer Variation Bronchoalveolar Lavage MESH: Aged 80 and over Bronchoscopy MESH: Microscopy Confocal Prospective Studies Prospective cohort study Lung Aged 80 and over Observer Variation MESH: Aged Microscopy Confocal medicine.diagnostic_test MESH: Bronchoalveolar Lavage Interstitial lung disease respiratory system MESH: Fluorescent Dyes MESH: Predictive Value of Tests MESH: Reproducibility of Results medicine.anatomical_structure Predictive value of tests MESH: Lasers Female Radiology MESH: Spectrometry Fluorescence medicine.drug Pulmonary and Respiratory Medicine medicine.medical_specialty MESH: Pneumonia MESH: Probability Sensitivity and Specificity Predictive Value of Tests medicine Humans MESH: Lung MESH: Bronchoscopy Aged Fluorescent Dyes Probability MESH: Humans business.industry Lasers MESH: Amiodarone Reproducibility of Results Pneumonia medicine.disease MESH: Sensitivity and Specificity MESH: Male MESH: Prospective Studies MESH: Vasodilator Agents Spectrometry Fluorescence Bronchoalveolar lavage Lung Diseases Interstitial business MESH: Female MESH: Lung Diseases Interstitial |
| Zdroj: | The European respiratory journal. Supplement. The European respiratory journal. Supplement., 2013, 42 (6), pp.1646-58. ⟨10.1183/09031936.00191911⟩ The European respiratory journal. Supplement., 2013, 42 (6), pp.1646-58 |
| ISSN: | 0904-1850 |
| DOI: | 10.1183/09031936.00191911⟩ |
| Popis: | International audience; Probe-based confocal laser endomicroscopy (pCLE) allows microscopic imaging of the alveoli during bronchoscopy. The objective of the study was to assess the diagnostic accuracy of pCLE for amiodarone-related pneumonia (AMR-IP). Alveolar pCLE was performed in 36 nonsmoking patients, including 33 consecutive patients with acute or subacute interstitial lung disease (ILD), of which 17 were undergoing treatment with amiodarone, and three were amiodarone-treated patients without ILD. Nine out of 17 patients were diagnosed with high-probability AMR-IP (HP-AMR-IP) by four experts, and three separate observers. Bronchoalveolar lavage findings did not differ between HP-AMR-IP and low-probability AMR-IP (LP-AMR-IP) patients. In HP-AMR-IP patients, pCLE showed large (>20 μm) and strongly fluorescent cells in 32 out of 38 alveolar areas. In contrast, these cells were observed in only two out of 39 areas from LP-AMR-IP patients, in one out of 59 areas from ILD patients not receiving amiodarone and in none of the 10 areas from amiodarone-treated patients without ILD (p |
| Databáze: | OpenAIRE |
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