Naturally occurring NS3-protease-inhibitor resistant mutant A156T in the liver of an untreated chronic hepatitis C patient
| Autor: | Silvia Sauleda, Teresa Otero, Jaume Guardia, Marta Bes, Juan Ignacio Esteban, Josep Quer, Rafael Esteban, Maria Cubero |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Adult
Male Macrocyclic Compounds Serine Proteinase Inhibitors Inhibitor Genes Viral Proline viruses medicine.medical_treatment Hepatitis C virus Molecular Sequence Data Mutant Hepacivirus Viral quasispecies Viral Nonstructural Proteins Biology medicine.disease_cause In vivo Sequence Homology Nucleic Acid Virology Drug Resistance Viral medicine Humans Point Mutation Protease inhibitor (pharmacology) Amino Acid Sequence NS3 Mutation Patient Protease Base Sequence Sequence Homology Amino Acid Serine Endopeptidases Hepatitis C Chronic HCV-NS3 Resistant Thiazoles Untreated Liver DNA Viral Quinolines Carbamates Oligopeptides |
| Zdroj: | Virology. 370(2):237-245 |
| ISSN: | 0042-6822 |
| DOI: | 10.1016/j.virol.2007.10.006 |
| Popis: | An increasing number of new hepatitis C virus NS3-protease inhibitors are being evaluated for the treatment of chronic hepatitis C. Treatment-induced selection of mutants conferring resistance to protease inhibitors has been shown both in vivo and in vitro. A specific mutation, A156T has been shown to confer high-level resistance to several such agents (BILN2061, VX-950, SCH446211 (SCH6) and SCH503034). Here we report the presence of the A156T mutation in close to 1% of NS3 sequences within the liver quasispecies of a chronic hepatitis C patient never treated with anti-NS3-protease inhibitors. |
| Databáze: | OpenAIRE |
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