Growth of human breast cancers in Peromyscus
| Autor: | Hippokratis Kiaris, Amanda Havighorst, Ioulia Chatzistamou, Vimala Kaza, Janet P. Crossland, Elena Farmaki |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Peromyscus medicine.drug_class medicine.medical_treatment Neuroscience (miscellaneous) Medicine (miscellaneous) lcsh:Medicine Mouse Models Breast Neoplasms General Biochemistry Genetics and Molecular Biology 03 medical and health sciences 0302 clinical medicine Breast cancer Immunology and Microbiology (miscellaneous) Cell Line Tumor medicine lcsh:Pathology Animals Humans Resource Article skin and connective tissue diseases Peromyscus californicus Diversity Outbred biology Fulvestrant Letrozole lcsh:R Immunosuppression biology.organism_classification medicine.disease Xenograft Model Antitumor Assays 3. Good health 030104 developmental biology Estrogen 030220 oncology & carcinogenesis Cancer research Mammary cancer Female Heterogeneity medicine.drug Hormone lcsh:RB1-214 |
| Zdroj: | Disease Models & Mechanisms, Vol 11, Iss 1 (2018) Disease Models & Mechanisms |
| ISSN: | 1754-8411 1754-8403 |
| Popis: | Modeling breast cancer in general and hormone-sensitive breast cancer, in particular in mice, has several limitations. These are related to the inbred nature of laboratory mice, and do not allow adequate appreciation of the contribution of the host's genetic heterogeneity in tumor growth. In addition, the naturally low estrogen levels of mice makes estradiol supplementation obligatory for tumor growth. Here, we show that Peromyscus californicus, following cyclosporine-mediated immunosuppression, supports the growth of both MDA-MB-231 estrogen-independent and MCF7 estrogen receptor-positive breast cancers without exogenous estradiol supplementation. Tumor growth was inhibited by fulvestrant or letrozole, confirming that MCF7 xenografts remain hormone dependent in vivo and suggesting that P. californicus can be used as an alternative to conventional mice for the study of hormone-sensitive breast cancer. The fact that Peromyscus stocks are outbred also facilitates the study of breast cancer in genetically heterogenous populations. Summary: Outbred stocks of Peromyscus californicus (California mice), upon pharmacological immunosuppression, provide an alternative to conventional inbred mice models, and can support the growth of hormone-insensitive and hormone-sensitive human breast cancers. |
| Databáze: | OpenAIRE |
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