Experimental sleep restriction increases latency jitter in pain elicited cortical responses
| Autor: | Kristian Bernhard Nilsen, Trond Sand, J.O. Hansen, Dagfinn Matre, Petter Moe Omland |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Painful Stimulation Pain Jitter Electroencephalography Audiology Phase locking 03 medical and health sciences 0302 clinical medicine Event-related potential Medicine Event related potential EEG lcsh:Social sciences (General) lcsh:Science (General) Sleep restriction Multidisciplinary medicine.diagnostic_test business.industry Latency jitter Sleep in non-human animals 030104 developmental biology Cortical response lcsh:H1-99 business Sleep 030217 neurology & neurosurgery lcsh:Q1-390 Research Article |
| Zdroj: | 291-? Heliyon Heliyon, Vol 7, Iss 2, Pp e06188-(2021) |
| Popis: | Objective Previous studies have shown increased pain scores to painful stimulation after experimental sleep restriction, but reduced or unchanged magnitude of the event related potentials (ERPs) when averaged in the time-domain. However, some studies found increased response magnitude when averaging in the time-frequency domain. The aim of this study was to determine whether ERP-latency jitter may contribute to this discrepancy. Methods Ninety painful electrical stimuli were given to 21 volunteers after two nights of 50% sleep restriction and after two nights of habitual sleep. ERPs were analyzed in the time-domain (N2-and P2-peaks) and time-frequency domain (power spectral density). We quantified latency jitter by the mean consecutive difference (MCD) between single-trial peak latencies and by phase locking value (PLV) across trials. Results P2-MCD increased from 20.4 ± 2.1 ms after habitual sleep to 24.3 ± 2.2 ms after sleep restriction (19%, p = 0.038) and PLV decreased from 0.582 ± 0.015 after habitual sleep to 0.536 ± 0.015 after sleep restriction (7.9%, p = 0.009). We found no difference for N2-MCD. Conclusions Our results indicate that partial sleep restriction increase latency jitter in cortical responses to experimental pain. Significance Latency jitter may contribute to the discrepancies between ERP-responses in the time-frequency domain and time-domain. Latency jitter should be considered when ERPs are analyzed. Sleep, Pain, Jitter, Event related potential, EEG, Cortical response |
| Databáze: | OpenAIRE |
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