Copper complexes with a flexible piperazinyl arm: nuclearity driven catecholase activity and interactions with biomolecules
| Autor: | Shaikh M. Mobin, Charmier Maria Adilia Januario, Indrani Choudhuri, Susana Morgado, Poulami Mandal, Suman Mukhopadhyay, Biswarup Pathak, Mriganka Das, Novina Malviya |
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| Rok vydání: | 2016 |
| Předmět: |
Gel electrophoresis
Schiff base 010405 organic chemistry Stereochemistry chemistry.chemical_element 010402 general chemistry 01 natural sciences Medicinal chemistry Copper 0104 chemical sciences chemistry.chemical_compound Monomer chemistry Octahedron Pyridine Materials Chemistry Moiety Physical and Theoretical Chemistry Conformational isomerism |
| Zdroj: | Journal of Coordination Chemistry. 69:3619-3637 |
| ISSN: | 1029-0389 0095-8972 |
| DOI: | 10.1080/00958972.2016.1236193 |
| Popis: | Three new Cu(II) complexes, [Cu(HL1)(pyridine)(H2O)](ClO4)2·2MeOH (1), [Cu2(HL1)2(NO3)2](NO3)2·3H2O (2) and [Cu(HL2)(NO3)2]·MeCN (3), have been synthesized from two Schiff base ligands [HL1 = 1-phenyl-3-((2-(piperazin-4-yl)ethyl)imino)but-1-en-1-ol and HL2 = 4-((2-(piperazin-1-yl)ethyl)imino)pent-2-en-2-ol] by using the chair conformer of a flexible piperazinyl moiety. Structural analysis reveals that 1 and 3 are monomeric Cu(II) complexes consisting of five- and six-coordinate Cu(II), respectively, whereas 2 is a dinuclear Cu(II) complex consisting of two different Cu(II) centers, one square planar with the other distorted octahedral. Screening tests were conducted to quantify the binding of 1, 2 and 3 towards DNA and BSA as well as the DNA cleavage activity of these complexes using gel electrophoresis. Enzyme kinetic studies were also performed for the complexes mimicking of catecholase like activities. Antibacterial activities of these complexes were also examined towards Methicillin-Resistant Staphylococcus aureus (MRSA) bacteria. The results reflect that 2 is more active than the monomeric complexes, which is further corroborated by DFT study. |
| Databáze: | OpenAIRE |
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