Hippocampal Context Processing during Acquisition of a Predictive Learning Task Is Associated with Renewal in Extinction Recall
| Autor: | Silke Lissek, Martin Tegenthoff, Benjamin Glaubitz, Tobias Schmidt-Wilcke |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Adult
Male Cognitive Neuroscience Statistics as Topic Context (language use) Hippocampal formation Hippocampus 050105 experimental psychology Extinction Psychological Task (project management) Developmental psychology Young Adult 03 medical and health sciences 0302 clinical medicine Predictive Value of Tests Image Processing Computer-Assisted Humans 0501 psychology and cognitive sciences Predictive learning Brain Mapping Recall 05 social sciences Novelty Association Learning Extinction (psychology) Magnetic Resonance Imaging Associative learning Mental Recall Multivariate Analysis Female Psychology Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Journal of Cognitive Neuroscience. 28:747-762 |
| ISSN: | 1530-8898 0898-929X |
| DOI: | 10.1162/jocn_a_00928 |
| Popis: | Renewal is defined as the recovery of an extinguished response if extinction and retrieval contexts differ. The context dependency of extinction, as demonstrated by renewal, has important implications for extinction-based therapies. Persons showing renewal (REN) exhibit higher hippocampal activation during extinction in associative learning than those without renewal (NOREN), demonstrating hippocampal context processing, and recruit ventromedial pFC in retrieval. Apart from these findings, brain processes generating renewal remain largely unknown. Conceivably, processing differences in task-relevant brain regions that ultimately lead to renewal may occur already in initial acquisition of associations. Therefore, in two fMRI studies, we investigated overall brain activation and hippocampal activation in REN and NOREN during acquisition of an associative learning task in response to presentation of a context alone or combined with a cue. Results of two studies demonstrated significant activation differences between the groups: In Study 1, a support vector machine classifier correctly assigned participants' brain activation patterns to REN and NOREN groups, respectively. In Study 2, REN and NOREN showed similar hippocampal involvement during context-only presentation, suggesting processing of novelty, whereas overall hippocampal activation to the context–cue compound, suggesting compound encoding, was higher in REN. Positive correlations between hippocampal activation and renewal level indicated more prominent hippocampal processing in REN. Results suggest that hippocampal processing of the context–cue compound rather than of context only during initial learning is related to a subsequent renewal effect. Presumably, REN participants use distinct encoding strategies during acquisition of context-related tasks, which reflect in their brain activation patterns and contribute to a renewal effect. |
| Databáze: | OpenAIRE |
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