Blueberries Improve Pain, Gait Performance, and Inflammation in Individuals with Symptomatic Knee Osteoarthritis
| Autor: | Young-Hoo Kwon, Keith Crabtree, Parakat Vijayagopal, Chen Du, Wanyi Wang, Amy Smith, Shanil Juma, Sanique South, Marco Avalos |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Male medicine.medical_specialty WOMAC Activities of daily living Blueberry Plants lcsh:TX341-641 Osteoarthritis Walking Placebo gait Article knee osteoarthritis 03 medical and health sciences 0302 clinical medicine Quality of life Double-Blind Method Internal medicine Medicine Humans pain 030212 general & internal medicine polyphenols Aged Pain Measurement blueberry 030109 nutrition & dietetics Nutrition and Dietetics business.industry Middle Aged Osteoarthritis Knee medicine.disease Gait Preferred walking speed inflammation Female Inflammation Mediators business lcsh:Nutrition. Foods and food supply Food Science Blood drawing |
| Zdroj: | Nutrients, Vol 11, Iss 2, p 290 (2019) Nutrients Volume 11 Issue 2 |
| ISSN: | 2072-6643 |
| Popis: | Osteoarthritis (OA) is the most common joint disorder in the world and is the most frequent cause of walking related disability among older adults in the US, which brings a significant economic burden and reduces quality of life. The initiation and development of OA typically involves degeneration or progressive loss of the structure and function of articular cartilage. Inflammation is one of the major drives of the progression of OA. Dietary polyphenols have been studied for their anti-inflammatory properties and potential anabolic effects on the cartilage cells. Blueberries are widely consumed and are high in dietary polyphenols, therefore regular consumption of blueberries may help improve OA. The purpose of the present study was to examine the effect of freeze dried whole blueberries on pain, gait performance, and inflammation in individuals with symptomatic knee OA. In a randomized, double-blind trial, adults age 45 to 79 with symptomatic knee OA, were randomized to either consume 40 g freeze-dried blueberry powder (n = 33) or placebo powder (n = 30) daily for four months. Blood draws and assessment of pain and gait were conducted at baseline, two months, and four months. Western Ontario McMaster Osteoarthritis Index (WOMAC) questionnaires were used to assess pain and GAITRite® electronic walkway was used to evaluate gait spatiotemporal parameters. WOMAC total score and sub-groups, including pain, stiffness, and difficulty to perform daily activities decreased significantly in the blueberry treatment group (p < 0.05), but improvement of WOMAC total score and difficulty to perform daily activities were not observed in the placebo group. Normal walking pace single support percentage for both limbs increased (p = or < 0.007), while double support percentage for both limbs decreased in the blueberry treatment group (p = or < 0.003). No significant changes were observed in plasma concentrations of tumor necrosis factor (TNF)-&alpha interleukin (IL)-1&beta IL-6, IL-10, IL-13, matrix metalloproteinases (MMP)-3, MMP-13, and monocyte chemoattractant protein-1 (MCP-1) in both treatment groups. However, an increasing trend for IL-13 concentration and a decreasing trend in MCP-1 concentration were noted in the blueberry group. The findings of this study suggest that daily incorporation of whole blueberries may reduce pain, stiffness, and difficulty to perform daily activities, while improving gait performance, and would therefore improve quality of life in individuals with symptomatic knee OA. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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