Myelin insulation as a risk factor for axonal degeneration in autoimmune demyelinating disease
| Autor: | Markus Morawski, Erik Schäffner, Daniel S. Reich, Stefan A. Berghoff, K.-A. Nave, Peter Wieghofer, Alexander Flügel, Martin Krueger, M Lehning, J Strauß, Julia M. Edgar, Ruth M. Stassart, Alonso Barrantes-Freer, M Bosch-Queralt, Marco Prinz, Christine Stadelmann, Robert Fledrich, Tilo Reinert, Wiebke Möbius |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Autoimmune disease
0303 health sciences Pathology medicine.medical_specialty business.industry Multiple sclerosis medicine.disease 03 medical and health sciences Myelin 0302 clinical medicine medicine.anatomical_structure nervous system Demyelinating disease medicine Extracellular Risk factor business Axonal degeneration 030217 neurology & neurosurgery 030304 developmental biology |
| Zdroj: | bioRxiv |
| Popis: | Axonal degeneration determines the clinical outcome of multiple sclerosis (MS), and is thought to result from exposure of denuded axons to immune-mediated damage. We challenge this view after finding in MS and its mouse models that myelin itself increases the risk of axons to degenerate under inflammatory conditions. We propose a model for demyelinating diseases in which for axons that remain myelinated, and thus shielded from the extracellular milieu, dependence from oligodendroglial support turns fatal in an autoimmune disease environment. |
| Databáze: | OpenAIRE |
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