Consortium for Dural Arteriovenous Fistula Outcomes Research (CONDOR): rationale, design, and initial characterization of patient cohort

Autor: Ridhima Guniganti, Enrico Giordan, Ching-Jen Chen, Isaac Josh Abecassis, Michael R. Levitt, Andrew Durnford, Jessica Smith, Edgar A. Samaniego, Colin P. Derdeyn, Amanda Kwasnicki, Ali Alaraj, Adriaan R. E. Potgieser, Samir Sur, Stephanie H. Chen, Yoshiteru Tada, Ethan Winkler, Ryan R. L. Phelps, Pui Man Rosalind Lai, Rose Du, Adib Abla, Junichiro Satomi, Robert M. Starke, J. Marc C. van Dijk, Sepideh Amin-Hanjani, Minako Hayakawa, Bradley A. Gross, W. Christopher Fox, Diederik Bulters, Louis J. Kim, Jason Sheehan, Giuseppe Lanzino, Jay F. Piccirillo, Akash P. Kansagra, Gregory J. Zipfel, Hari Raman, Kim Lipsey, Waleed Brinjikji, Roanna Vine, Harry J. Cloft, David F. Kallmes, Bruce E. Pollock, Michael J. Link, Mohana Rao Patibandla, Dale Ding, Thomas Buell, Gabriella Paisan, R. Michael Meyer, Cory Kelly, Jonathan Duffill, Adam Ditchfield, John Millar, Jason Macdonald, Adam J. Polifka, Dimitri Laurent, Brian Hoh, Ashley Lockerman, L. Dade Lunsford, Brian T. Jankowitz, Santiago Ortega Gutierrez, David Hasan, Jorge A. Roa, James Rossen, Waldo Guerrero, Allen McGruder, Fady T. Charbel, Victor A. Aletich, Linda Rose-Finnell, Eric C. Peterson, Dileep R. Yavagal, Yasuhisa Kanematsu, Nobuaki Yamamoto, Tomoya Kinouchi, Masaaki Korai, Izumi Yamaguchi, Yuki Yamamoto, Michael Lawton, Martin Rutkowski, M. Ali Aziz-Sultan, Nirav Patel, Kai U. Frerichs
Přispěvatelé: Movement Disorder (MD)
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Journal of Neurosurgery, 136(4), 951-961. AMER ASSOC NEUROLOGICAL SURGEONS
ISSN: 0022-3085
Popis: OBJECTIVE Cranial dural arteriovenous fistulas (dAVFs) are rare lesions, hampering efforts to understand them and improve their care. To address this challenge, investigators with an established record of dAVF investigation formed an international, multicenter consortium aimed at better elucidating dAVF pathophysiology, imaging characteristics, natural history, and patient outcomes. This report describes the design of the Consortium for Dural Arteriovenous Fistula Outcomes Research (CONDOR) and includes characterization of the 1077-patient cohort. METHODS Potential collaborators with established interest in the field were identified via systematic review of the literature. To ensure uniformity of data collection, a quality control process was instituted. Data were retrospectively obtained. RESULTS CONDOR comprises 14 centers in the United States, the United Kingdom, the Netherlands, and Japan that have pooled their data from 1077 dAVF patients seen between 1990 and 2017. The cohort includes 359 patients (33%) with Borden type I dAVFs, 175 (16%) with Borden type II fistulas, and 529 (49%) with Borden type III fistulas. Overall, 852 patients (79%) presented with fistula-related symptoms: 427 (40%) presented with nonaggressive symptoms such as tinnitus or orbital phenomena, 258 (24%) presented with intracranial hemorrhage, and 167 (16%) presented with nonhemorrhagic neurological deficits. A smaller proportion (224 patients, 21%), whose dAVFs were discovered incidentally, were asymptomatic. Many patients (85%, 911/1077) underwent treatment via endovascular embolization (55%, 587/1077), surgery (10%, 103/1077), radiosurgery (3%, 36/1077), or multimodal therapy (17%, 184/1077). The overall angiographic cure rate was 83% (758/911 treated), and treatment-related permanent neurological morbidity was 2% (27/1467 total procedures). The median time from diagnosis to follow-up was 380 days (IQR 120–1038.5 days). CONCLUSIONS With more than 1000 patients, the CONDOR registry represents the largest registry of cranial dAVF patient data in the world. These unique, well-annotated data will enable multiple future analyses to be performed to better understand dAVFs and their management.
Databáze: OpenAIRE
Externí odkaz: