Individual differences in the effects of cannabinoids on motor activity, dopaminergic activity and DARPP-32 phosphorylation in distinct regions of the brain

Autor: Maria Dosi, Christina Spyraki, Andreas Galanopoulos, Marios Marselos, Zeta Papadopoulou-Daifoti, Katerina Antoniou, George G. Nomikos, Alexia Polissidis, Olga Chouliara, Georgia Rentesi, Thomas Hyphantis, Eleni T. Tzavara
Rok vydání: 2009
Předmět:
Male
Dopamine and cAMP-Regulated Phosphoprotein 32
Dopamine
Morpholines
medicine.medical_treatment
Poison control
Striatum
Dopamine/*metabolism
Morpholines/administration & dosage/pharmacology
Motor Activity
Naphthalenes
Nucleus accumbens
Pharmacology
Nucleus Accumbens
Naphthalenes/administration & dosage/pharmacology
Rats
Sprague-Dawley
Neurochemical
Brain/*drug effects/metabolism
medicine
Animals
Cannabinoids/*pharmacology
Pharmacology (medical)
Dronabinol
Phosphorylation
Analgesics/administration & dosage/pharmacology
Prefrontal cortex
Analgesics
Behavior
Animal
Dose-Response Relationship
Drug
Cannabinoids
Dopaminergic
Dopamine and cAMP-Regulated Phosphoprotein 32/*metabolism
Phosphorylation/drug effects
Brain
Corpus Striatum
Benzoxazines
Rats
Corpus Striatum/drug effects/metabolism
Nucleus Accumbens/drug effects/metabolism
Motor Activity/*drug effects
Psychiatry and Mental health
Tetrahydrocannabinol/*pharmacology
Cannabinoid
Benzoxazines/administration & dosage/pharmacology
Psychology
Behavior
Animal/*drug effects
medicine.drug
Zdroj: The International Journal of Neuropsychopharmacology. 13:1175-1191
ISSN: 1469-5111
1461-1457
DOI: 10.1017/s1461145709991003
Popis: This study explored the behavioural, neurochemical and molecular effects of Delta9-tetrahydrocannabinol (Delta9-THC) and WIN55,212-2, in two rat phenotypes, distinguished on the basis of their vertical activity upon exposure to a novel environment, as high responders (HR) and low responders (LR). Motor effects were assessed under habituated vs. non-habituated conditions. Dopaminergic activity and DARPP-32 phosphorylation were measured in the dorsal striatum, nucleus accumbens, prefrontal cortex and amygdala. These cannabinoids influenced motor activity in a biphasic manner, i.e. low doses stimulated, whereas high doses suppressed motor activity. Dopamine (DA) biosynthesis was increased in most brain regions studied following Delta9-THC administration mainly in HR rats, and low-dose WIN55,212-2 increased DA biosynthesis in HR rats only. Both high and low doses of Delta9-THC increased DARPP-32 phosphorylation in most brain regions studied in both phenotypes, an effect that was also observed following high-dose WIN55,212-2 administration only in the striatum. The present results provide further support for a key role of cannabinoids in the regulation of motoric responses and elements of dopaminergic neurotransmission and reveal their complex differential effects in distinct rat phenotypes, as seen with other drugs of abuse. Int J Neuropsychopharmacol
Databáze: OpenAIRE
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