Neuropeptide B mediates female sexual receptivity in medaka fish, acting in a female-specific but reversible manner
| Autor: | Yoshitaka Nagahama, Yuji Nishiike, Kaito Ishikawa, Junpei Yamashita, Masato Kinoshita, Yukiko Kikuchi, Yukika Kawabata-Sakata, Kataaki Okubo, Towako Hiraki-Kajiyama, Mikoto Nakajo, Daichi Miyazoe, Kohei Hosono, Satoshi Ansai, Keiko Yokoyama |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Neuropeptide B female receptivity medicine.drug_class sexual lability QH301-705.5 media_common.quotation_subject Science Oryzias mating behavior Biology General Biochemistry Genetics and Molecular Biology Courtship sex steroid Sexual Behavior Animal 03 medical and health sciences 0302 clinical medicine Mediator medicine Animals Mating neuropeptide B Biology (General) Gene knockout reproductive and urinary physiology media_common General Immunology and Microbiology General Neuroscience Neuropeptides Estrogens General Medicine Cell biology Sexual dimorphism 030104 developmental biology Gene Expression Regulation Estrogen Sex steroid sexual dimorphism Medicine Female Other 030217 neurology & neurosurgery Research Article Neuroscience |
| Zdroj: | eLife, Vol 8 (2019) eLife |
| Popis: | Male and female animals display innate sex-specific mating behaviors. In teleost fish, altering the adult sex steroid milieu can effectively reverse sex-typical mating behaviors, suggesting remarkable sexual lability of their brains as adults. In the teleost medaka, neuropeptide B (NPB) is expressed female-specifically in the brain nuclei implicated in mating behavior. Here, we demonstrate that NPB is a direct mediator of estrogen action on female mating behavior, acting in a female-specific but reversible manner. Analysis of regulatory mechanisms revealed that the female-specific expression of NPB is dependent on direct transcriptional activation by estrogen via an estrogen-responsive element and is reversed in response to changes in the adult sex steroid milieu. Behavioral studies of NPB knockouts revealed that female-specific NBP mediates female receptivity to male courtship. The female-specific NPB signaling identified herein is presumably a critical element of the neural circuitry underlying sexual dimorphism and lability of mating behaviors in teleosts. |
| Databáze: | OpenAIRE |
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