Difference in the Lubrication Efficiency of Bovine and Vegetable-Derived Magnesium Stearate During Tabletting
| Autor: | Mobin A. Tawakkul, Mazen L. Hamad, Mansoor A. Khan, Abhay Gupta, Vilayat A. Sayeed |
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| Rok vydání: | 2009 |
| Předmět: |
Materials science
Compressive Strength High Shear Granulation Pharmaceutical Science Aquatic Science Granulation chemistry.chemical_compound Vegetables Drug Discovery Animals Technology Pharmaceutical Dissolution testing Magnesium stearate Composite material Fluid Bed Granulation Dissolution Ecology Evolution Behavior and Systematics Lubricants Ecology General Medicine Compressive strength chemistry Lubrication Cattle Agronomy and Crop Science Stearic Acids Research Article Tablets |
| Zdroj: | AAPS PharmSciTech. 10:500-504 |
| ISSN: | 1530-9932 |
| DOI: | 10.1208/s12249-009-9229-y |
| Popis: | The purpose of this work was to evaluate and compare the functionality of bovine fatty acids-derived (MgSt-B) and vegetable fatty acids-derived (MgSt-V) magnesium stearate powders when used for the lubrication of granules prepared by high-shear (HSG) and fluid bed (FBG) wet granulation methods. The work included evaluation of tablet compression and ejection forces during tabletting and dissolution testing of the compressed tablets. Granules prepared by both granulation methods required significantly lower ejection force (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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