Urine albumin/creatinine ratio for the assessment of albuminuria in pregnancy hypertension
| Autor: | Rune Bäck, Maria Trygg, Henry Nisell |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Gestational hypertension
medicine.medical_specialty Urology Renal function Urine Urinalysis Preeclampsia chemistry.chemical_compound Pre-Eclampsia Pregnancy Internal medicine medicine Albuminuria Humans Creatinine Proteinuria business.industry Albumin Obstetrics and Gynecology Hypertension Pregnancy-Induced General Medicine Creatine medicine.disease Endocrinology chemistry Female medicine.symptom business |
| Zdroj: | Acta Obstetricia et Gynecologica Scandinavica. 85:1327-1330 |
| ISSN: | 1600-0412 0001-6349 |
| Popis: | An accurate method to assess albuminuria in pregnancy is mandatory to diagnose pre-eclampsia. Twenty-four-hour urine collection is still the only universally accepted method. This is, however, a cumbersome and inconvenient method. Therefore, the present study aimed at assessing the accuracy of a spot urine albumin/creatinine ratio in pregnant women with hypertension.In 54 pregnant women with blood pressureor=140/90 mmHg, 24-h albumin excretion and subsequent albumin/creatinine ratio on morning spot urine were analyzed in the individual patients. Altogether 75 paired samples were included. Receiver operating characteristic curves, relating different albumin/creatinine ratio cut-off values to 24-h albumin excretion300 mg were constructed. Correlations were assessed by Spearman rank correlation tests.The area under the receiver operating characteristic curve was 0.985. At the optimal cut-off albumin/creatinine ratio value of 27 mg/mmol the sensitivity, specificity, positive and negative predictive value for detecting albuminuria300 mg/24 h were: 95, 100, 100 and 86% respectively. There was a close correlation between albumin/creatinine ratio and 24-h albumin excretion values (r=0.95; p0.001).It is suggested that in most cases the more cumbersome 24-h urine collection can be replaced by the more convenient albumin/creatinine ratio on spot urine. |
| Databáze: | OpenAIRE |
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