The Relationship Between Flow-Mediated Dilatation of the Brachial Artery and Intima-Media Thickness of the Carotid Artery to Framingham Risk Scores in Older African Americans
| Autor: | Shichen Xu, Abid R. Maqbool, John Kwagyan, Saifudin Hussein, Muluemebet Ketete, Otelio S. Randall, Robert H. Schneider |
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| Rok vydání: | 2009 |
| Předmět: |
Male
medicine.medical_specialty Brachial Artery Carotid Artery Common Endocrinology Diabetes and Metabolism Carotid arteries Statistics as Topic Risk Assessment Internal medicine medicine.artery Internal Medicine medicine Humans cardiovascular diseases Endothelial dysfunction Brachial artery National Cholesterol Education Program Reactive hyperemia Aged Ultrasonography Aged 80 and over Analysis of Variance Framingham Risk Score business.industry Age Factors Middle Aged medicine.disease Original Papers United States Black or African American Vasodilation Compliance (physiology) Intima-media thickness Cardiovascular Diseases Cerebrovascular Circulation Multivariate Analysis cardiovascular system Cardiology Regression Analysis Female Endothelium Vascular Tunica Intima Tunica Media Cardiology and Cardiovascular Medicine business Dilatation Pathologic |
| Zdroj: | J Clin Hypertens (Greenwich) |
| ISSN: | 1751-7176 1524-6175 |
| DOI: | 10.1111/j.1751-7176.2009.00175.x |
| Popis: | The objective of this study was to investigate the relationship of flow‐mediated dilatation and intima‐media thickness (IMT) with coronary risk in African Americans (AAs). Endothelial dysfunction and IMT of carotid arteries are considered early steps in atherosclerotic disease process and have been used as surrogate markers of subclinical atherosclerosis. Data were collected on 106 AAs with a mean age of 64.0±6.6 years. Carotid artery IMT was measured with B‐mode ultrasonography, as was brachial artery diameter at rest, during reactive hyperemia, and after nitroglycerin. Percent change in flow‐mediated dilatation (%FMD) was defined as 100×(diameter during reactive hyperemia – resting diameter)/resting diameter. Percent change in nitroglycerin‐mediated dilatation (%NMD) was defined as 100×(diameter with nitroglycerin‐resting diameter)/resting diameter. The Framingham 10‐year risk score (FRS) was calculated for each patient using the National Cholesterol Education Program (NCEP) risk score calculator and participants were categorized into 3 groups with FRS as 20%. Thirty‐eight participants had risk scores 20%. There was a significant inverse relation between %FMD and FRS (P |
| Databáze: | OpenAIRE |
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