Intraoperative radiation therapy and hyperthermia. Morbidity and mortality from this combined treatment modality for unresectable intra-abdominal carcinomas
| Autor: | Christopher T. Coughlin, Evan B. Douple, Thomas A. Colacchio, Robert W. Crichlow, James H. Taylor, T.P. Ryan |
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| Rok vydání: | 1990 |
| Předmět: |
Hyperthermia
medicine.medical_specialty Modality (human–computer interaction) Intraoperative Care business.industry medicine.medical_treatment Ultrasonic Therapy Carcinoma Locally advanced Radiotherapy Dosage Hyperthermia Induced medicine.disease Combined Modality Therapy Surgery Pancreatic Neoplasms Combined treatment Evaluation Studies as Topic Abdominal Neoplasms medicine Humans Neoplasm Recurrence Local business Colorectal Neoplasms Intraoperative radiation therapy |
| Zdroj: | Archives of surgery (Chicago, Ill. : 1960). 125(3) |
| ISSN: | 0004-0010 |
| Popis: | • This is a report of a phase I trial of intraoperative radiation therapy in combination with intraoperative hyperthermia for the treatment of locally advanced, unresectable intra-abdominal carcinomas. Using an ultrasound transducer system specifically designed for intraoperative applications, 19 patients have been successfully treated, demonstrating the feasibility of this combination modality. The morbidity (58%) and mortality (11%) rates reported in this series are comparable to rates reported in series of similar patients receiving intraoperative radiation therapy alone. There is still a great need for considerable technological development to enable the use of intraoperative hyperthermia to treat large, complexly shaped intra-abdominal tumors, and phase II and III trials of this combination treatment modality should be performed. (Arch Surg.1990;125:370-375) |
| Databáze: | OpenAIRE |
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